Effect of Metformin on Parameters of Insulin Resistance in Patients with Primary Hypothyroidism

Tamara Vatseba

Abstract


The research examined the frequency and nature of carbohydrate metabolism disorders in patients with primary hypothyroidism. In 25.8% of patients increased glycemic indexes responding to a prediabetes stage were found. In patients with thyroid hypofunction (TG) the presence of insulin resistance (IR) by defined HOMA IR and Caro indexes has been proved. The dependence of IR severity on heaviness of hypothyroidism and BMI has been determined.

Differentiated treatment of patients with primary hypothyroidism, obesity and initial carbohydrate metabolism disorders has demonstrated the priority of efficiency of combination therapy with appointed metformin and levothyroxine in comparison with the basic substitution therapy. Appointment of metformin for the treatment of the patients with proven IR contributed to the rapid compensation of hypothyroidism, normalization of carbohydrate metabolism indexes, and it is also preventing the possible development of metabolic syndrome.


Keywords


hypothyroidism; insulin resistance; obesity; metformin; thyroxin

Full Text:

HTML PDF

References


Kihtyak OP, Skrypnyk NV, Pasyechko NV. Changes of carbohydrate and lipid metabolism in patients with hypothyroidism syndrome. Bull Sci Res. 2012;2:27–8

Mitchenko OI, Logvynenko AO, Romanov VY. Optimization of treatment dyslipidemia and disorders of carbohydrate metabolism in patients with arterial hypertension with metabolic syndrome and thyroid dysfunction. Ukr J Cardiol. 2010;1:73–80

Mosqua HA, Lapovets LE, Kihtyak OP. Features correlations of insulin resistance, carbohydrate and lipid metabolism in patients with hypothyroidism. Bull Probl Biol Med. 2013;3:212–6

Pankiv VI. Syndrome hypothyroidism. Pract Thyroidol. 2011;3:224

Mitchenko OI, Logvynenko AO, Romanov VY. Cardiovascular risk against the background of thyroid dysfunction. Heal Ukr. 2012;20(297):27–9

Skrypnyk NV. Method diagnostic of hypothyroidism-induced metabolic syndrome. Bucovina Med Bull. 2009;3:83–8

Sokolova LK. Metformin. Today and future of famous drug. J Endocrinol. 2012;17(1):89–93

Tronko MD, Myshunina TN, Kalinichenko OV. Mechanisms of apoptosis thyroid conditions at its pathology. Physiol J. 2009;55(6):90–102

Biondi V. Cardiovascular risk in subclinical hypothyroidism. In: Materials I Forum of endocrinology «Treatment of subclinical hypothyroidism in children, women and adults»; 10-12 May 2013; Baveno-Stresa; p. 73–75

Brenta G. Why can insulin resistance be a natural consequence of thyroid dysfunction? J Thyroid Res. 2011;152:850 DOI: http://doi.org/10.4061/2011/152850

Lozanov V, Argirova R, Lozanov L. Hypothyroidism, central obesity and metabolic syndrome correlations between thyroid stimulathing hormone, adipocitokines and indiced of insulin resistens. Eur Thyroid J. 2014;3:122




DOI: http://dx.doi.org/10.21802/gmj.2017.1.5

Copyright (c) 2017 Tamara Vatseba

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.


IFNMU Logo

Free counters!