Peculiarities of Biomechanical Properties of Ocular Tissue in Keratoconus
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Keywords

keratoconus
biomechanical properties
rigidity
coefficient of corneal rigidity
fibrous tunic of eyeball

Abstract

Considerable achievements having been recently made in modern diagnostics and treatment of keratoconus have not diminished the urgency of the given problem as the traditional views of the pathogenesis of keratoconus do not always allow to struggle effectively with this difficult and continuously progressing disease.The objective of the research was to study the peculiarities of biomechanical properties of the cornea in keratoconus.Materials and methods. The article presents the analysis of studying biomechanical properties of the cornea in keratoconus. 44 patients (88 eyes) with keratoconus and emmetropic refraction were examined. To calculate biomechanical indicators of the cornea there was carried out the comparative analysis between the measurements obtained with the use of several methods in the same patients, namely the Oculus Pentacam-Scheimpflug imaging device by a standard technique and the indicators calculated using the method proposed by us and the device for in vivo estimation of corneal rigidity.Results. Considerable advantages of using the developed method and the device for estimation of corneal rigidity in vivo in comparison with keratotopography on the Oculus Pentacam-Scheimpflug camera were registered which allowed us not only to reveal the presence of biomechanical disorders of the cornea, but also to differentiate their character. To describe the degree of changes in biomechanical properties of the cornea in vivo the coefficient of corneal rigidity was developed.Conclusions. Loading tests allow receiving more exact information on biomechanical properties of the cornea in comparison with standard researches on the Oculus Pentacam-Scheimpflug camera.
https://doi.org/10.21802/gmj.2016.4.21
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References

Balashevich LI, Kachanov AB, Nikulin SA, Golovatenko SP, Bauer SM, Zimin BA. Aberrometricheskie issledovaniya pri emmetropii i miopii. Sbornik trudov IV mezhregionalnogo seminara “Biomekhanika glaza 2004”. 2004;4:14–17

Belin М. Pentacam: opyt primeneniya v vedushchikh klinikakh Rossii i mira. Novoe v oftalmologii. 2011;4:74–79

Erichev VP. Kornealnyi gisterezis v norme i pri nekotorikh vidakh oftalmopatologii. Biomekhanika glaza - 2007: Sb. trud. konf; Moscow. 2007. p. 82–87

Zhuravlyov AI, Malyshev LK, Saulgozis YuZh, Nekrasov YuD, Pavilaynen VYa. Sovremennoe sostoyanie i perspektivy primeneniya metoda fotouprugosti voftalmologiyi. Oftalmol zhurnal. 1990;8:479–482

Kivaev AA, Babich GA, Abugova TD. Dinamiks biomikroskopicheskikh izmeneniy rogovitsy pri keratokonuse. Oftalmologicheskiy zhurnal. 1979;4:217–218

Moiseenko RO, Golubchikov MV, Slabkiy GO, Rikov SO. Oftalmolohichna dopomoha v Ukraiini za 2006-2011 roky. Kyiv: c2012. 183 p.

Pasechnikova NV, Zavgorodnyaya TS, Dragomiretskaya EI. Diagnosticheskiye kriterii keratokonusa s uchetom iskhodnykh parametrov rogovitsy i ikh znachenie v klassifikatsii. Oftalmologicheskiy zhurnal. 2012;1:4–8

Sergienko NM, Shargorodska IV , inventors; Sergienko NM, Shargorodska IV , assignees. Pribor dlya otsenki rigidnosti rogovoy obolochki glaza. Ukrainian patent UA 85810. 2009 Feb 25

Sergienko NM, Shargorodska IV , inventors; Sergienko NM, Shargorodska IV , assignees. Sbosob otsenki rigidnosti rogovoy obolochki glaza. Ukrainian patent UA 39262. 2009 Feb 25

Shargorodska IV. Sravnitelnoy analiz izmereniya biokhemicheskikh pokazateley rogovitsy pri ispolzovanii razlichnykh metodov. Arkhiv oftalmologii Ukrainy. 2016;1:61–66

Eskina EN, Fedorova VN. Izmenenie nekotorikh mekhanicheskikh svoystv tkaney glaza v resultate eksimer-lazernoy fotoablyatsii s tselyu korrektsii astigmatizma i dalnozorkosti. Glaz. 2002;3(25):31–36

Amsler M. La notion du keratocone. Bull Soc Franc Ophthalmol. 1951;64(2):272–275

Brubaker RF, Ezekiel S, Chin L, Young L, Johnson SA, Beeler GW. The stress-strain behaviour of the corneoscleral envelope of the eye I. Development of a system for making in vivo measurements using optical interferometry. Exp Eye Res. 1975;21:37–46. DOI: http://doi.org/10.1016/0014-4835(75)90055-X

Duke-Elder S. Keratoconus. System of Ophthalmology; Henry Kimpton (London). 1965;8(2):964–976

Forster W, Kasprzak H, Bally G, Busse H. Qualitative Analyse der Elastizitat der rinderkornea durch holographische Interferometrie. Klin Mbl Augenheilk. 1992;200:54–59. DOI: http://doi.org/10.1055/s-2008-1045716

Iwaszkiewicz E, Rogowki I. Niektore Dane epidemiologczne. Klin Oczna. 1989;91(7-9):208–209

Kerautret J, Collin J, Touboul D, Roberts C. Biomechanical characteristics of the ecstatic cornea. J Cataract Refract Surg. 2008;34:510–513. DOI: http://doi.org/10.1016/j.jcrs.2007.11.018

Kotecha A, Elsheikh A, Roberts CR, Zhu H, Garway-Heath DF. Corneal thickness - and age-related biomechanical properties of the cornea measured with the ocular response analyzer. Invest Ophthalmol Vis Sci. 2006;47:5337–5347. DOI: http://doi.org/10.1167/iovs.06-0557

Lichtinger A, Rootman DS. Intraocular lenses for presbyopia correction: past, present, and future. Curr Opin Ophthalmol. 2012;23(1):40–46. DOI: http://doi.org/10.1097/ICU.0b013e32834cd5be

Liu WC, Lee SM, Graham AD, Lin MC. Effects of eye rubbing and breath holding on corneal biomechanical properties and intraocular pressure. Cornea. 2011;30:855–860. DOI: http://doi.org/10.1097/ICO.0b013e3182032b21

Liu J, Roberts CJ. Influence of corneal biomechanical properties on intraocular pressure measurement; quantitative analysis. J Cataract Refract Surg. 2005;31:146–155. DOI: http://doi.org/10.1016/j.jcrs.2004.09.031

Luce DA. Determining in vivo biomechanical properties of the cornea with an ocular response analyzer. J Cataract Refract Surg. 2005;31:156–162. DOI: http://doi.org/10.1016/j.jcrs.2004.10.044

Mandell RB, Chiang CS, Yee L. Asymmetric corneal toricity and pseudokeratoconus in videokeratography. J Am Optom Assoc. 1996;67(9):540–547

Marsack J, Milner T, Rylander D, et al. Applying wave front sensors and corneal topography to keratoconus. Biomed Sci Instrum. 2002;38:471–476

McMonnies CW. Corneal hysteresis using the Ocular Response Analyzer. Optometry and Vision Science. 2012;89(3):1–7. DOI: http://doi.org/10.1097/OPX.0b013e3182417223

Mikielewicz M, Kotliar K, Barraquer RI, Michael R. Air-pulse corneal applanation signal curve parametres for the characterisation of keratoconus. Br J Ophthalmol. 2011;95:793–798. DOI: http://doi.org/10.1136/bjo.2010.188300

Ohanecian OG, Danilova DU, Gundorova RA, Eremina MB. Change of biomechanical properties of eye after DLEK. Vestnik of ophthalmology. 2009;4:9–11

Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998;42(4):297–319. DOI: http://doi.org/10.1016/S0039-6257(97)00119-7

Rabinowitz YS, Nesbum AB, McDonnell PJ. Videokeratography of the fellow eye in unilateral keratoconus. Ophthalmology. 1993;100(2):181–186

Reinstein DZ, Gobbe M, Archer TJ. Ocular biomechanics: measurement parametres and terminology. J Refract Surg. 2011;27:396–397. DOI: http://doi.org/10.3928/1081597X-20110519-01

Sergienko NM, Shargorodska IV. Determining corneal hysteresis and preexisting intraocular pressure. J Cataract Refract Surg. 2009;35:2033–2034. DOI: http://doi.org/10.1016/j.jcrs.2009.06.028

Sergienko NM, Kondratenko YN, Tutchenko NN. Depth of focus in pseudophakic eyes. Graefe`s Archive for Clinical and Experimental Ophthalmology. 2007;246(11):1623–1627. DOI: http://doi.org/10.1007/s00417-008-0923-3

Shah S, Laiquzzaman M, Bhojwani R, Mantry S, Cunliffe I. Assessment of the biomechanical properties of the cornea with the ocular response analyzer in normal and keratoconic eyes. Invest Ophthalmol Vis Sci. 2007;48:3026–3031. DOI: http://doi.org/10.1167/iovs.04-0694

Takacs L, Csutac A, Balazc E, et al. Expression of betaig-h3 is lower than normal in keratoconus corneas but increases with scarring. Cornea. 1999;18(5):599–605. DOI: http://doi.org/10.1097/00003226-199909000-00014

Wygledowska-Promienska D, Zawojska I. Procedure for keratoconus detection according to the Rabinowitz-Rasheed method-personal. Klin Oczna. 2000;102(4):241–244

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