Changes in the Dynamics of Treating Patients with Generalized Periodontitis and Hypertension Depending on the Method of Treatment
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Keywords

hypertension
generalized periodontitis
Ca

Abstract

Calcium and its compounds play an important role in the regulation of many functions of the body. The concentration of calcium ions in the serum is one of the important constants of homeostasis. The objective of the research was to study the level of total calcium, ionized calcium, and phosphorus in patients with stage II hypertension and generalized periodontitis of II degree of severity, depending on the method of treatment. Materials and methods. The main group consisted of 70 patients with generalized periodontitis of II degree of severity and stage II hypertension who were divided into 4 groups. The comparison group consisted of 30 patients suffering from generalized periodontitis of II degree of severity without hypertension who were divided into similar 4 groups depending on age and type of treatment. The control group included 17 patients of corresponding age with healthy periodontium and without somatic pathology. Results. Twelve months after starting treatment, in younger patients of the main group receiving basic therapy, serum phosphorus level increased by 0.03 mmol /l, and in the older ones, it increased by 0.04 mmol/l. In younger and older patients of the comparison group, serum phosphorus level increased by 0.05 mmol/l. The patients who received basic therapy in combination with the proposed scheme of treatment had higher level of phosphorus than those who received basic therapy only. Twelve months after starting treatment, serum level of total calcium decreased in young and older patients of the main group and comparison group receiving basic therapy. An obvious improvement of treatment 12 months after its starting was observed in all the patients of the main group and comparison group who received basic therapy in combination with the proposed scheme of treatment. Conclusions. The improved treatment scheme was more effective for treatment of generalized periodontitis of II degree of severity in patients with stage II hypertension.
https://doi.org/10.21802/gmj.2018.4.11
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References

Biryukova EV. Osteoporosis: point of view of endocrinologist. Pharmateca. 2012;1-12:32-39.

Chang WT, Radin B, McCurdy MT. Calcium, magnesium, and phosphate abnormalities in the emergency department. Emerg Med Clin North Am. 2014;32(2):349-366. DOI: https://doi.org/10.1016/j.emc.2013.12.006

Cortellini P, Tonetti MS. Clinical and radiographic outcomes of the modified minimally invasive surgical technique with and without regenerative materials: a randomized-controlled trial in intra-bony defects. J Clin Periodontol. 2011;38(4):365-373. DOI: https://doi.org/10.1111/j.1600-051X.2011.01705.x

Courbebaisse M, Souberbielle JC. Phosphocalcic metabolism: regulation and explorations. Nephrol Ther. 2011;7(2):118-138. [published in French] DOI: https://doi.org/10.1016/j.nephro.2010.12.004

Dedukh NV, Poshelok DM, Malyshkina SV. Modeling and remodeling bone (review). Ukraiinskyi stomatolohichnyi almanakh. 2014;12(1):107-111. [published in Russian]

Demidov VI, Zhidomorov NYu, Gromova OA et al. Meaning of calcium, D3 vitamin and osteotropic minerals in treatment and complex therapy of cannon-bone fracture: the results of randomized placebo-controlled experiment. Lechashchiy vrach. 2014;12:42-46. [published in Russian]

Ghosh AK, Joshi SR. Disorders of calcium, phosphorus and magnesium metabolism. J Assoc Physicians India. 2008;56:613-621. [PMid:19051708]

Gusak EV, Pogorelov MV, Tkach GF et al.The elementary compound of the long and mix bones. Ukraiinskyi morfolohichnyi almanakh. 2010;8(4):51-55. [published in Ukrainian]

Hussain QA, McKay IJ, Gonzales-Marin C, Allaker RP. Regulation of adrenomedullin and nitric oxide production by periodontal bacteria. J Periodontal Res. 2015;50(5):650-657. DOI: https://doi.org/10.1111/jre.12246

Hussain QA, McKay IJ, Gonzales-Marin C, Allaker RP. Detection of adrenomedullin and nitric oxide production in different forms of periodontal disease. J Periodontal Res. 2016;51(1):16-25. DOI: https://doi.org/10.1111/jre.12273

Kamilov FKh. Cellular and molecular mechanisms remodelling of bone tissue and regulation. Fundamentalnyye isledovaniya.2014;7:836-842. [published in Russian]

Krishnan V, Mani Sundar N, Krishnaraj S et al. Comparison of the salivary and the serum nitric oxide levels in chronic and aggressive periodontitis: a biomechanical study. Journal of Clinical and Diagnostic Research. 2013;7(6):1223-1227. [PMid:23905146 PMCid:PMC3708241]

Kutya SA. Age-related features of calcium-phosphorus metabolism in rats exposed to gravitational overloads. Ukraiinskyi morfolohichnyi almanakh. 2009;4:80-82.

Kuvayev AS, Borysenko AV, Viderskaya AV. Experimental and clinical substantiation of nitric oxide metabolism correction in the complex therapy of patients with generalized periodontitis. Ukrainian Scientific Medical Youth Journal. 2015;91(4):108-112.

Masalova NN, Zakharenko RV. Normal calcium-phosphor and bone metabolism and its disorders in thyroid dysfunctions. Dalnevostochnyy meditsinskiy zhurnal. 2009;2:122-125. [published in Russian]

Netyukhaylo LG, Filatova VL, Filatova AV. Water-salt exchange. Visnyk problem biolohii i medytsyny. 2012;1(91):32-37. [published in Ukrainian]

Peacock M. Calcium metabolism in health and disease. Clin J Am Soc Nephrol. 2010;5(1):23-30. DOI: https://doi.org/10.2215/CJN.05910809

Povoroznyuk VV, Grigoryeva NV. Pitaniye i kostnaya tkan. Problemy stareniya i dolgoletiya. 2011;20(2):148-158.

Rozhinskaya LYa. Diagnostika i lecheniye osteoporoza. Klinicheskaya gerentologiya. 2007;2:37-46.

Shevchuk VH, Moroz VM, Bielan SM et al. Fiziolohiia: pidruchnyk dlia stud. vyshch. med. navch. zakladiv. Shevchuk VH, editor. Vinnytsia: Nova knyha; c2012. 448p.

Yakymiuk DI, Kryvetskyi VV, Banul BYu, Kryvetskyi IV. Modern views on the growth, development and morphogenesis of the human skeleton. Bukovynskyi medychnyi visnyk. 2013;17(2):181-185. [published in Ukrainian]

Zoellner H. Vascular response in chronic periodontitis. Semin Thromb Hemost. 2011;2(37):181-182. DOI: https://doi.org/10.1055/s-0031-1273082 [PMid:21455852]

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