AbstractThe preparations of polyhydric alcohols, namely sorbitol-based ones, and their combination with adjuvant therapy, namely L-arginine are sufficiently promising for treatment of purulent-septic complications. The systemic nature of their action makes it appropriate to carry out studies of specific effect on the circulatory system, since their wide homeostatic and pharmacodynamic spectrum is beyond doubt for other systems and organs within the “efficiency-safety” algorithm.The objective of the research was to study the effect of combined use of sorbilact and L-arginine on the cardiovascular system of patients with endogenous intoxication syndrome during the period of developing early secondary autoaggression.Materials and methods. The study included 117 patients who were divided into the following groups: Group I consisted of 31 patients with systemic inflammatory response syndrome; Group II included 27 patients with endogenous intoxication syndrome treated according to 2016 Surviving Sepsis Campaign; Group ІІI comprised 29 patients with endogenous intoxication syndrome who received sorbilact in addition to standard therapy; Group IV included 30 patients with systemic inflammatory response syndrome who received standard therapy as well as sorbilact and L-arginine.Results. Co-administration of sorbilact and L-arginine was accompanied by an increase in stroke volume and cardiac output, activation of left ventricular minute work alongside with a moderate decrease in mean arterial pressure and systemic vascular resistance.Conclusions. The application of sorbilact and L-arginine in patients with endogenous intoxication syndrome provides hemodynamic stability.
Gelfand BR, Protsenko DN, Gelfand EB. Sepsis: clinical and pathophysiological concept, diagnosis and intensive care. Consilium medicum. 2017;19(7-1):8-14. [published in Russian]
Gasanov MD. Formation of algorithms to determine the severity of endotoxemia in peritonitis. Khirurgiia (Mosk). 2015;(1):54-57. [published in Russian] DOI: https://doi.org/10.17116/hirurgia2015154-57
Peck TE, Hill S. Pharmacology for Anaesthesia and Intensive Care. Cambridge Medicine. 2008;3:378. DOI: https://doi.org/10.1017/CBO9780511722172
Alliev NA, Bobilev AB, Khamidov DB, Barotov ED, Buriiev TN, Kurbanov DA et al. Rheosorbilact and latren in the correction of endogenous intoxication and oxidative stress in patients with acute destructive pancreatitis. Meditsina neotlozhnykh sostoyaniy. 2015;1(64):57-59. [published in Russian]
Neirynck N, Eloot S, Glorieux G, Barreto DV, Barreto FC, Liabeuf S, Vanholder R et al. Estimated glomerular filtration rate is a poor predictor of the concentration of middle molecular weight uremic solutes in chronic kidney disease. PLoS One. 2012;7(8): e44201. DOI: https://doi.org/10.1371/journal.pone.0044201
Morozova TE, Khoseva EN, Vartanova OA. Control over the safety of drugs: practical issues of pharmacovigilance: manual. Meditsinskoye informatsionnoye agentstvo. c2014. 112p.
Nichitailo ME. Application of Sorbilact in the treatment and prophylaxis of postoperative intestinal paresis after reconstructive operations on the biliary ducts. Klin Khir. 2011;(6):30-31. [published in Russian]
Konovchuk VM, Andrushchak AV, Maksymchuk NO. Method of evaluation of the course of endogenous intoxication. Ukrainian patent UA 112508. 2016.
Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Rochwerg B et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017;43(3):304-377. DOI: https://doi.org/10.1007/s00134-017-4683-6
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.