AbstractThere were studied 92 somatically healthy persons of young age (18-25 years old), with generalized periodontitis (GP) of initial-I degree of development, among them: 30 patients with chronic generalized periodontitis (CGP), who were included into group І; and 32 patients with exacerbation of the chronic generalized periodontitis (ECGP) – into group II; and 30 healthy patients. The carbohydrate metabolism indexes were studied, namely: the content of glucose, pyruvate (pyruvic acid) and lactate (lactic acid) and lactate dehydrogenase activity (LDG) in the oral liquid.We have determined that in the presence of CGP of the initial-I degree of development, and especially in its exacerbation, there is a significant increase of indicators of carbohydrate metabolism. In young patients with CGP indicators of glucose, pyruvate, lactate and LDG activity in the oral liquid increased by 2.0, 1.34, 1.58 and 1.37 (p<0.001, p<0.01) times respectively, and in case of ECGP they grew even more: by 2.71, 1.98, 1.76 and 2.07 (p<0.001) times, respectively.Among all the indicators, that characterize the carbohydrate metabolism, in addition to the level of pyruvate, in case of different course of GP a significant difference was revealed: in patients with ECGP compared with the data in CGP, glucose and lactate levels and LDG activity in the oral liquid were significantly higher - at 35.75% (p<0.05), 34.29% (p<0.01) and 36.59% (p<0.001) respectively.Detected violations of carbohydrate metabolism indeces in the oral liquid indicate the involvement of these processes in the pathogenesis of GP and the necessity of their correction.
Antonenko MYu. Scientific substantiation of the modern strategy of prophylaxis of periodontal diseases in Ukraine: author's abstract of dissertation of PhD: 14.01.22, "Dentistry". Ukr. medical stomat. Academy. 2012; 40.
Balakhovsky IS, Natochin YuV. Problems of space biology. Science. 2006; ХХІІ: 32.
Borisenko AV. Periodontal Diseases: training manual (Secrets of Therapeutic Dentistry). VSI "Meditsina". 2013; 456.
Veremeyenko KM, Kyzym OY. Biochemistry of oral secretion and its research in the clinic. Laboratory diagnostics. 2005; 2 (32): 9-14.
Orekhova LYu et al. Periodontal diseases. Poli Media Press. 2004; 432.
Kamyshnev VS. Reference book on clinical-biochemical studies and laboratory diagnostics. 2004; 476.
Malyy DYu, Antonenko MYu. Epidemiology of periodontal diseases: the age aspect. Ukrainian scientific-medical youth magazine. 2013; 4: 41-43.
Melnychuk AS, Rozhko MM, Ersteniuk AM. Some indicators of protein and bone exchange in patients with generalized periodontitis in partial loss of teeth. Sovremennaya stomatologiya. 2012; 24-26.
Menshikov VV. Laboratory methods of research in the clinic. Reference book. Meditsina. 1987; 174-175.
Lastukhin YuO, Voronov SA. Organic Chemistry. Tsentr Evropy. 2006; 196.
Pasechnik AV, Moiseeva EG, Frolov VA, Drozdova GA. Periodontitis and metabolic abnormalities. Training-methodical guideline. Izd-vo. 2011; 30.
Tarasenko LM, Neporada KS, Hryhorenko VH. Functional biochemistry. Nova knyha. 2007; 384.
Tkachenko AH. Peculiarities of clinical course, treatment and prophylaxis of generalized periodontitis in young people aged 18-25 years: author's abstract for PhD. 14.01.22 "Dentistry". Nats. Un-t im. O.O. Bogomolets. 2006; 19.
Hakkinen L, Oksala O, Solo T, Rahemtulla F. Immuno-histochemical localization of proteoglycans in human periodontium. J. Histochem. Cytochem. 1993; 41:1689. DOI: https://doi.org/10.1177/41.11.8409375 [PMid:8409375]
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.