Mechanism Development of Diabetic Microangiopathy and Opportunity of Diabetic Warning

S. M. Genyk


Specific general defeat of arteriols, capillaries and veins at a diabet mellitus consists in the bulge of basale membrane of shallow vessels, laying of glycoproteins in a wall and proliferation of endothelium. A hyperglycaemia results in increasing of blood plasma, membranes and cages of level of free radicals on a background insufficiency of enzymes of the protective antioxidant system. Determination of the state insulin tolerance to the people with excessive body weight and obesity, by a hyperpiesis, problems with the lack of fats, by a gout and other endocrine diseases already on the stage of credible violation of carbohydrate exchange gives an opportunity in good time to conduct the correction of possible defeats of microvasculature toxic action of high concentration of glucose.


hyperglycemia; tolerance of insulin; sugaring haemoglobin; microcirculation; diabetic angiopathy

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Alleman C.J., Westerhout K.Y., Hensen M. et al. Humanistic and economic burden of painful diabetic peripheral neuropathy in Europe: A review of the literature. Diabetes Res. Clin. Pract. 2015; 2: 215-225. DOI: [PMid:26008721]

Bellamy L., Casas J.P., Hingorani A.D., Williams D. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet. 209; 373: 1773-1779.

Borch-Jahnsen K., Cologiuri S. Diagnosing diabetes-time for a change ? Diabetologia. 2009; 52: 2247-2250. DOI: [PMid:19756480]

Buchanan T.A., Xiang A.H., Peters R.K. et al. Preservation of pancreatic beta-cell function of type 2 diabetes by pharmacological treatment of insulin resistence in high-risk Hispanic voman. Diabetes. 2002; 51: 2796-2803. DOI: [PMid:12196473]

Callaghan B.C., Cheng H.T., Stables C.L. et al. Diabetic neuropathy: clinical manifestations and current treatment. Lancet Neurol. 2012; 6; 521-534. DOI:

Dzyak L.A., Zozulya O.A. Diabetic Polyneuropathy (Ethiopathogenesis, Clinical Picture, Diagnostics, Treatment). International Neurological Journal. 2008; 4: 61-72.

Genyk S.M. Surgical treatment of diabetic foot syndrome. Heart vessels. 2017; 2: 121-126.

Insel R.A., Dunne J.L., Atkinson M.A. et al. Staging presymptomatic type 1 diabetes a scientific statement of JDRF, the Endocrine Society and the American Diabetesassociation. Diabetes Care. 2015; 38: 1964-1974. DOI: [PMid:26404926 PMCid:PMC5321245]

Javed S., Alam U., Malik R.A. Treating Diabetic Neuropathy: Present Strategies and Emerging Solutions. Rev. Diabet. Stud. 2015; 1-2: 63-83. DOI: [PMid:26676662 PMCid:PMC5397984]

Jovanovic A., Stolic R.V., Rasic D.V. et al. Stroke and diabetic ketoacidosis - some diagnostic and therapeutic considerations. Vasc. Health. Risk. Monag. 2014; 10: 201-204. DOI: [PMid:24748799 PMCid:PMC3986295]

Khyzhnyak O.O., Mikityuk M.R., Karachentsev Yu.I. Treatment of diabetic prolyneuropathy. International journal of endocrinology. 2017; 1:65-70.

Koppensteiner R. Hemotheology and angiology. Fortschr. Med. 2012; 7: 108-110.

Kozlov G.S. Microangiopathy in Tine 2 Diabetes Mellitus: Mechnisms of of Development, Possibilities of Prevention, Treatment. Kardiologia. 2009; 11: 56-63.

Laakso M., Kuusisto J. Insulin resistance and hyperglycaemia in cardiovascular disease development. Nat.Rek.Endocrinol. 2014; 5: 293-302. DOI: [PMid:24663222]

Lie M.L., Hayes L., Lewis-Barned N.J., May C., White M., Bell R. Preventing type 2 diabetes after gestational diabetes: womens experiences and implications for diabetes prevention interventions. Diabet Med. 2013; 30: 986-993. DOI: [PMid:23534548]

Martovitskaya Yu.V. Pathomorphological displays of diabetic microangiopathy and neuropathy according to the research of the amputated extremities in patients with the diabetic foot syndrome. Pathologia. 2007; 3: 42-46.

Pankiv V.I. Disordes of carbohydrate metabolism in clinical practice. International journal of endocrinology. 2017; 1: 59-65.

Papanas N., Ziegler D. Efficacy of lipoic acid in diabetic neuropathy. Expert Opin Pharmacother. 2014; 18: 2721-2731. DOI: [PMid:25381809]

Reaven G.M. Relationships among insulin resistance, type 2 diabetes, essential hypertension, and cardiovascular disease: similarities and differences. J.Clin.Hypertens. 2011; 4: 238-243. DOI: [PMid:21466618]

Shaw J.E., Sicree R.A., Zimmet P.Z. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res. Clin.Prac. 2010; 1:4-14. DOI: [PMid:19896746]

Skyler J.S., Bakris G.L., Bonifacio E. et al. Differentiation of diabetes by pathophysiology, natural bistory, and prognosis, Diabetes. 2016; 10: 2337-2343.

Standards of Medical Care in Diabetes. Diabetes Care. 2017; 40: 54-55. DOI: [PMid:27999002]

Thomas M.C., Walker M.K., emberson J.R. et al. Prewabence of undiagnosed Type 2 diabetes and impaired fasting glucose in older British men and woman. Diabet. Med. 2005; 6: 789-793. DOI: [PMid:15910633]

Vinik A., Nevoret M., Casellini C. et al. Diabetic neuropathy: Endocrinol. Metab.Clin.North.Am.2013; 4:747-787. DOI: [PMid:24286949]

Volmer-Thole M., Lobmann R. Neuropathy and Diabetic Foot Syndrome. Int. J. Mol. Sci. 2016; 6: 3390-3397. DOI:

Yang W., Dall T.M., Halder P. Economic costs of diabetes in the U.S. in 2012. Diabetes Care. 2013; 4: 1033-1046.


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