Study of Macro- and Microelement Status in Patients with Nodular Goiter Residing in Kyiv Region

V. Kravchenko, I. Luzanchuk, I Andrusyshyna, M. Polumbrik


Sixty-one residents of Kiev region (16 individuals with nodular goiter and 45 individuals without thyroid pathology – the control group) were examined. When studying urinary iodine excretion, median urinary iodine concentration in the control group was 65.0 μg/l, while in patients with nodular goiter, it was 72.15 μg/l indicating mild iodine deficiency. In patients with nodular goiter, there were observed decreased serum levels of calcium - 74.17 mg/l (p<0.05), magnesium - 17.67 mg/l, zinc - 0.73 mg/l (p<0.05) and selenium - 0.03 mg/l (p<0.05) as compared to those in the control group. The relative risk of developing nodular goiter in decreased serum calcium concentration was 1.66 (95% confidence interval 1.07-2.09), (p<0.05); in decreased serum concentration of both calcium and selenium, it was 2.30 (95% confidence interval 1.147–4.085), (p<0.05); in low serum magnesium concentration, the relative risk was 2.6 (95% confidence interval 1.11-6.09) (p<0.05). 


iodine deficiency; thyroid gland; nodular goiter; urinary iodine excretion; macro- and microelements; relative risk of developing diseases

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