Evaluation of Arterial Stiffness in Patients with Bronchial Asthma and Co-Existent Chronic Obstructive Pulmonary Disease

Kseniia Nazarenko

Abstract


The objective of the research was to determine the characteristics of arterial stiffness and cardiovascular risk in patients with co-existence of asthma and chronic obstructive pulmonary disease.

Materials and methods. The study included patients with symptoms of chronic obstructive pulmonary disease, those with asthma and chronic obstructive pulmonary disease and the group of apparently healthy individuals.

Results. In patients with obstructive lung disease, the parameters of vascular stiffness and central blood pressure reflecting the degree of cardiovascular risk were significantly higher as compared to those in apparently healthy individuals. They were significantly elevated in patients with chronic obstructive pulmonary disease and asthma-chronic obstructive pulmonary disease overlap. The indicators of central blood pressure were significantly higher in patients with asthma-chronic obstructive pulmonary disease overlap and more pronounced bronchial obstruction, and in patients with more obvious symptoms of obstructive pathology. Excess body weight or obesity had a strong and pronounced effect on the parameters of central blood pressure in patients with asthma-chronic obstructive pulmonary disease overlap. In patients with a comorbidity, a reliable correlation between the indicator of the presence of pulmonary hyperinflation and the degree of arterial stiffness was revealed.

 


Keywords


asthma-COPD overlap; arterial stiffness; cardiovascular risk

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References


Hines KL, Peebles RS Jr. Management of the Asthma-COPD Overlap Syndrome (ACOS): a Review of the Evidence. Curr Allergy Asthma Rep. 2017; 17 (3): 15. DOI: https://doi.org/10.1007/s11882-017-0683-4

Feshchenko YuI, Pertseva TA, Yashina LA et al. Bronkhialnaya astma i khronicheskoye obstruktivnoye zabolevaniye legkikh v svete novykh rekomendatsiy. Zdorovia Ukraiiny. 2014; 4: 3-5.

Franssen F, Rochester C. Comorbidities in patients with COPD and pulmonary rehabilitation: do they matter? European Respiratory Review. 2014; 23: 131-141. DOI: https://doi.org/10.1183/09059180.00007613

Fisher KA, Stefan MS, Darling C et al. Impact of COPD on the mortality and treatment of patients hospitalized with acute decompensated heart failure: the Worcester Heart Failure Study. Chest. 2015; 147 (3): 637-645. DOI: https://doi.org/10.1378/chest.14-0607

Divo M, Cote C, de Torres JP et al. Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012; 186 (2): 155-161. DOI: https://doi.org/10.1164/rccm.201201-0034OC

de Lucas-Ramos P, Izquierdo-Alonso JL, Rodriguez-Gonzalez Moro JM et al. Chronic obstructive pulmonary disease as a cardiovascular risk factor. Results of a case-control study (CONSISTE study). Int J Chron Obstruct Pulmon Dis. 2012; 7: 679-686. DOI: https://doi.org/10.2147/COPD.S36222

de Miguel Díez J, Chancafe Morgan J, Jiménez García R. The association between COPD and heart failure risk: a review. Int J Chron Obstruct Pulmon Dis. 2013; 8: 305-312. DOI: https://doi.org/10.2147/COPD.S31236

Safar ME, Blacher J, Jankowski P. Arterial stiffness, pulse pressure, and cardiovascular disease - is it possible to break the vicious circle? Atherosclerosis. 2011; 218 (2): 263-271. DOI: https://doi.org/10.1016/j.atherosclerosis.2011.04.039

Luo K, Feng X, Xu B, Long H. Association between arterial stiffness and risk of coronary artery disease. Pak J Med Sci. 2014; 30 (6): 1314-1318. DOI: https://doi.org/10.12669/pjms.306.5584

Pandey A, Khan H, Newman A. Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure with Preserved Ejection Fraction, and Heart Failure with Reduced Ejection Fraction: the Health ABC Study (Health, Aging, and Body Composition). Hypertension. 2017; 69: 267-274. DOI: https://doi.org/10.1161/HYPERTENSIONAHA.116.08327

Chen Y, Shen F, Liu J, Yang G. Arterial stiffness and stroke: de-stiffening strategy, a therapeutic target for stroke. Stroke Vasc Neurol. 2017; 2: 65-72. DOI: https://doi.org/10.1136/svn-2016-000045

Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol. 2010; 55 (13): 1318-1327. DOI: https://doi.org/10.1016/j.jacc.2009.10.061

Takashima N, Turin T, Matsui K et al. The relationship of brachial-ankle pulse wave velocity to future cardiovascular disease events in the general Japanese population: the Takashima Study. J Hum Hypertens. 2014; 28: 323-327. DOI: https://doi.org/10.1038/jhh.2013.103

Sheng CS, Li Y, Li LH et al. Brachial-ankle pulse wave velocity as a predictor of mortality in elderly Chinese. Hypertension. 2014; 64 (5): 1124-1130. DOI: https://doi.org/10.1161/HYPERTENSIONAHA.114.04063

Zhang Y, Agnoletti D, Xu Y, Wang JG et al. Carotid-femoral pulse wave velocity in the elderly. J Hypertens. 2014; 32 (8): 1572-1576; DOI: https://doi.org/10.1097/HJH.0000000000000187

Lu Y, Zhu M, Bai B et al. Comparison of Carotid-Femoral and Brachial-Ankle Pulse-Wave Velocity in Association with Target Organ Damage in the Community-Dwelling Elderly Chinese: the Northern Shanghai Study. J Am Heart Assoc. 2017; 6 (2): e004168. DOI: https://doi.org/10.1161/JAHA.116.004168

Sievi NA, Franzen D, Kohler M, Clarenbach CF. Physical inactivity and arterial stiffness in COPD. Int J Chron Obstruct Pulmon Dis. 2015; 10: 1891-1897.

Vivodtzev I, Tamisier R, Baguet JP et al. Arterial stiffness in COPD. Chest. 2014; 145 (4): 861-875. DOI: https://doi.org/10.1378/chest.13-1809

Vanfleteren LE, Spruit MA, Groenen MT et al. Arterial stiffness in patients with COPD: the role of systemic inflammation and the effects of pulmonary rehabilitation. Eur Respir J. 2014; 43 (5): 1306-1315. DOI: https://doi.org/10.1183/09031936.00169313

Mostovoi YuM. Bronkhialna astma, KHOZL ta sertsevo-sudynni zakhvoriuvannia. Zdorovia Ukraiiny. 2011; 3 (256): 30-31.

Tattersall MC, Guo M, Korcarz CE at al. Asthma predicts cardiovascular disease events: the multi-ethnic study of atherosclerosis. Arterioscler Thromb Vasc Biol. 2015; 35 (6): 1520-1525. DOI: https://doi.org/10.1161/ATVBAHA.115.305452

Sun W, Jin D, Li Y, Wang R. Increased arterial stiffness in stable and severe asthma. RespirMed. 2014; 108: 57-62.

Varol E. Arterial stiffness in patients with bronchial asthma; role of hypertension and antihypertensive drugs. RespirMed. 2015; 109: 1490. DOI: https://doi.org/10.1016/j.rmed.2014.06.012

Rosenbaum D, Giral P, Chapman J et al. Radial augmentation index is a surrogate marker of atherosclerotic burden in a primary prevention cohort. Atherosclerosis. 2013; 231: 436-441. DOI: https://doi.org/10.1016/j.atherosclerosis.2013.10.004

Kawada T. Augmentation index as an indicator of central arterial stiffness and indicators of carotid atherosclerosis by ultrasonography in relation to life stress. J Psychosom Res. 2015; 79: 171. doi: http: //dx.doi.org/10.1016/j.jpsychores.2015.04.013 DOI: https://doi.org/10.1016/j.jpsychores.2015.04.013

Janner J, Godtfredsen N, Ladelund S et al. The association between aortic augmentation index and cardiovascular risk factors in a large unselected population. J Hum Hypertens. 2012; 26: 476-484. DOI: https://doi.org/10.1038/jhh.2011.59 [PMid:21654851]

Albu A, Fodor D, Bondor C, Suciu O. Carotid arterial stiffness in patients with chronic obstructive pulmonary disease. Acta Physiol Hung. 2011; 98 (2): 117-127. DOI: https://doi.org/10.1556/APhysiol.98.2011.2.3

Laurent S, Cockcroft J, Van Bortel L et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006; 27: 2588-2605. DOI: https://doi.org/10.1093/eurheartj/ehl254

Kaess B, Rong J, Larson M et al. Relations of Central Hemodynamics and Aortic Stiffness with Left Ventricular Structure and Function: the Framingham Heart Study. Journal of the American Heart Association. 2016; 5: e002693. doi: https: //doi.org/10.1161/JAHA.115.002693.

Lau D, Middeldorp M, Brooks A et al. Aortic stiffness in lone atrial fibrillation: a novel risk factor for arrhythmia recurrence. PLoS One. 2013; 8 (10): e76776. doi: https: //doi.org/10.1371/journal.pone.0076776.

Davies JE, Lacy P, Tillin T et al. Excess pressure integral predicts cardiovascular events independent of other risk factors in the conduit artery functional evaluation substudy of Anglo-Scandinavian Cardiac Outcomes Trial. Hypertension. 2014; 64 (1): 60-68. DOI: https://doi.org/10.1161/HYPERTENSIONAHA.113.02838

Global Initiative for Asthma (GINA) What's new in GINA 2016? Available from: http: //chicagoasthma.org/wp-content/uploads/2016/07/Whats-new-in-GINA-2016.pdf

The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017. Available from: http: //goldcopd.org/gold-2017-global-strategy-diagnosis-management-prevention-copd/

Sin DD, Miravitlles M, Mannino DM et al. What is asthma-COPD overlap syndrome? Towards a consensus definition from a round table discussion. Eur Respir J. 2016; 48 (3): 664-673. DOI: https://doi.org/10.1183/13993003.00436-2016

Niiranen TJ, Kalesan B, Hamburg NM et al. Relative Contributions of Arterial Stiffness and Hypertension to Cardiovascular Disease: The Framingham Heart Study. J Am Heart Assoc. 2016; 5 (11): e004271. DOI: https://doi.org/10.1161/JAHA.116.004271

Keto J, Ventola H, Jokelainen J et al. Cardiovascular disease risk factors in relation to smoking behaviour and history: a population-based cohort study. Open Heart. 2016; 3 (2): e000358. DOI: https://doi.org/10.1136/openhrt-2015-000358

Stallones R. The association between tobacco smoking and coronary heart disease. Int J Epidemiol. 2015; 44: 735-743. DOI: https://doi.org/10.1093/ije/dyv124 [PMid:26174518]

Félix-Redondo FJ, Grau M, Baena-Díez JM et al. Prevalence of obesity and associated cardiovascular risk: the DARIOS study. BMC Public Health. 2013; 13: 542. DOI: https://doi.org/10.1186/1471-2458-13-542

Landsberg L, Aronne LJ, Beilin LJ et al. Obesity-related hypertension: pathogenesis, cardiovascular risk, and treatment: a position paper of the Obesity Society and the American Society of Hypertension. J Clin Hypertens (Greenwich). 2013; 15 (1): 14-33. DOI: https://doi.org/10.1111/jch.12049

Budweiser S, Jörres RA, Riedl T et al. Predictors of survival in COPD patients with chronic hypercapnic respiratory failure receiving noninvasive home ventilation. Chest. 2007; 131: 1650-1658. DOI: https://doi.org/10.1378/chest.06-2124




DOI: http://dx.doi.org/10.21802/gmj.2017.4.3

Copyright (c) 2018 Kseniia Nazarenko

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