The Use of Antihypoxant and Antioxidant Therapy in Comprehensive Treatment of Acute Small Intestinal Obstruction

V. D. Skrypko, O. I. Deltsova, A. O. Klymenko, M. H. Gonchar, P. I. Sheviak

Abstract


Indices of lipid peroxidation (LPO), middle weight molecules (MWM), and changes in the structure of the liver and the impact of Reamberin solution on them were analyzed in 202 patients with acute small intestinal obstruction (ASIO) and model of small intestinal obstruction (SIO) in 40 Vietnamese pigs. Endogenous intoxication indices were established to increase along with the increase in enteral deficiency. In case of ASIO increase in lipid peroxidation products,  MWM in serum,  and  decrease in ceruloplasmin  securities,  significant  changes  in  the  liver  (destruction of granular and smooth endoplasmic reticulum, mitochondria, hepatocytes nuclei) were observed. Surgical resolution of ASIO leads to further temporary deterioration of liver structure, increase in MWM, and indices of lipid peroxidation and decrease in ceruloplasmin levels. Prescription of antioxidant therapy in the postoperative period promotes reparative processes in hepatocytes and leads to normalization of endogenous intoxication indices in blood serum and helps reduce postoperative mortality.

Keywords


intestinal obstruction; liver; endogeneous intoxication; lipid peroxidation; Reamberin; ceruloplasmin

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References


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DOI: http://dx.doi.org/10.21802/gmj.2016.3.52

Copyright (c) 2017 V. D. Skrypko, O. I. Deltsova, A. O. Klymenko, M. H. Gonchar, P. I. Sheviak

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