Changes in Cognitive Functions of Pupils under Conditions of Iodine Deficiency

N. M. Voronych-Semchenko, S. V. Varunkiv, V. A. Semchenko, V. O. Voronych


Clinical and physiological examination of 38 children which latent hypothyroidism (the main group) and 176 apparently healthy persons of intact region (the control group) at the age from 8 to 17 years living in endemic region was carried out. To determine the functional state of the thyroid gland in blood serum the content of total triiodothyronine (Т3), total and free thyroxin (Т4, fТ4), thyroid-stimulating hormone (TSH) of adenohypophysis were determined as well as urinary iodine level was examined. The cognitive functions were characterized by the indices of attention as the result of correction test and rate of sensomotor reactions which were evaluated using modified Schulte tables. It was detected that in all children with latent hypothyroidism regardless of age work accuracy rate decreased, attention span increased slowly, fatigue developed early and rate of information analysis significantly reduced already within the first 5 minutes in comparison with analogical data in healthy children. When being tested children of the control group made fewer mistakes, the tempo of doing tasks remained higher for 5 minutes. There was a correlation between the indices of correction test, sensomotor reactions and data of thyroid status of pupils.


iodine deficiency; thyroid homeostasis; cognitive functions

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Barysheva ES. The role of trace elements in a functional and structural homeostasis of thyroid. Mizhnarodnyi endokrynolohichnyi zhurnal. 2010; 7: 15–25.

Huranych TV, Bahrii MM, Voronych-Semchenko NM. Effect of combined iodine deficiency and copper on structural and functional features of the hypothalamic-pituitary-thyroid system. Visnyk problem biolohii i medytsyny. 2014; 1 (4): 88-93.

Zelinska NB, Resnikova AL, Mamenko MYe. Goiter in children: clinical features, differential diagnosis, treatment. Sovremennaya pediatriya. 2006; 1 (10): 57-65.

Methods of iodine deficiency disorders study and their elimination monitoring. Guide for program managers. Moscow. Meditsina. 2003; 430.

Nykolyshyn LV, Bahrii MM, Popadynets OH, Voronych-Semchenko NM. Structural and functional features of the hypothalamic-pituitary-thyroid system in animals with iodine and selenium deficiency. Naukovyi visnyk Uzhhorodskoho universytetu. 2014; 1(49): 14-18.

Pankiv VI. Iodine deficiency disorders. Chernivtsi. BDMA. 2001; 100.

Utenina VV, Boev VM, Barysheva ES. Characteristics of mental performance of children with endemic goiter living in iodine deficiency region. Rossiyskiy pediatricheskiy zhurnal. 2000; 1: 17-20.

Shidlovskyi VO, Dekailo IM, Shidlovskyi OV. Iodine deficiency disorders: diagnosis, treatment, prevention. Ternopil. Ukrmedknyha. 2006; 84.

Martinez–Galan JR, Pedraza P, Santacana M. Early effect of iodine deficiency on radial glial cells of the hippocampus of the rat fetus. J. Clin. Invest. 1997; 99: 2701–2709. Doi: 10.1172/JCI119459

Copyright (c) 2017 N. M. Voronych-Semchenko, S. V. Varunkiv, V. A. Semchenko, V. O. Voronych

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