Analysis of Adverse Reaction of Analgesics, Antipyretics and Non-Steroidal Anti-Inflammatory Drugs Prescribed by Physicians of Health Care Facilities in Podilskyi Region during 2015


adverse reactions


The problem of medicines rational use exists all over the world. It concerns particularly analgesics, antipyretics and non-steroidal anti-inflammatory drugs (NSAIDs). In Ukraine the side effects caused by non-steroidal antiphlogistics rank the second place according to the prevalence among all registered cases.The objective of the research was to analyze adverse drug reaction report forms concerning adverse reactions caused by the use of NSAIDs, analgesics, antipyretics, and were submitted during 2015 to the Vinnytsia regional unit of the State Expert Center of the Ministry of Health of Ukraine.The conducted research showed that 1460 cases of adverse reactions (AR) or lack of efficacy of medication (LOE) were registered in Vinnytsia region in 2015. Among all registered cases of AR with proven causal relationships (94.4%) caused by NSAIDs, there were 42.4% of AR caused by diclofenac sodium, 24.2% caused by ibuprofen, 10.6% caused by paracetamol, 9.1% caused by analginum (metamizole sodium) and 7.6% caused by nimesulide.The classification of patients according to age showed inhomogeneity in these medications prescription: ibuprofen and acetaminophen were taken mostly by teenagers, analginum was raken by young people and older people took mostly nimesulide. Diclofenac retained the stable position of “the gold standard” in the treatment and was evenly administered to patients of all ages.In addition, diclofenac and nimesulide were determined to be mostly prescribed to patients with rheumatologic pathology and ibuprofen, paracetamol and analgin were prescribed for the treatment of acute respiratory viral infections (hyperthermal syndrome). It should be noticed that allergic reactions dominated among the manifestations of adverse reactions of the studied drugs.


Viktorov AP, Maltsev VI, Belousov YB. The safety of medicines. Guidance on Pharmacovigilance. Kyiv. 2007; 240.

Vіktorov OP, Kashuba OV. Problems and prospects of getting information about side effects caused by NSAIDs on the basis of anonymous survey of patients (the look at the problem). Ukrainskyi medychnyi chasopys. 2010; 6: 7-10.

Dougan EV. Choosing safe NSAID – in search of the “Solomonic decision”. Manage pain. 2016; 1: 18-13.

Katerenchuk IP. The adverse reaction to NSAIDs and their optimal choice in family practice physician. Simeina medytsyna. 2010; 1: 19-28.

Kashuba OV. Side effects caused by the use of nonsteroidal anti-inflammatory drugs – analgesic-antipyretics. Ukrainskyi medychnyi chasopys. 2015. Available from:

Kashuba OV. Comparative features of adverse reactions caused by NSAIDs diclofenac and nimesulide. Ukrainskyi medychnyi chasopys. 2009; 2(70): 129-135.

Kashuba OV. Assessment of adverse reactions of certain NSAID. Liky Ukrainy. 2005; 12: 101-105.

Matveeva OV, Zimenkovsky BS, Yaychenya VP. The side effects of medications, their connection with drug-related and medical errors. Upravlinnia zakladom okhorony zdorodia. 2012; 6: 1-11.

Matveeva OV, Zimenkovsky BS, Yaychenya VP. The side effects of medications, their connection with drug-related and medical errors (Report II). Ratsionalnaya farmakoterapiya. 2013; 1: 5-17.

Chekman IS, Viktorov OP, Gorchakova NО, Svintsitskyi AS, et al. Non-steroidal anti-inflammatory drugs: efficiency, availability and acceptability for the patient. Pharmacovigilance for drug use safety. Polygraph Plus. Kyiv. 2011; 117.

Oleshchuk OM, Posokhova KA, Matiuk LM. The side effects of NSAIDs during their medical use. Proceedings of the scientific conference “Actual issues of pathology on conditions of influence of extreme effects in body”. Ternopil. 2015; 68.

Posokhova KA, Oleszczuk OMб Volska AS, Matiuk LM. The side effects of NSAIDs during their medical use in the Ternopil region. Proceedings of the XXXII Conference “Medicines – man”. Kharkiv. 2015; 97.

Illiash MG, Shevchenko TL, Bazyka OE, Some SI, et al. Side effects caused by analgesics, antipyretics during their medical use. Ratsionalnaya farmakoterapiya. 2013; 4(29): 23-27.

Posokhova KA, Oleszczuk OM, Shevchuk OO. The organization of work with pharmacovigilance tasks. Proceedings of scientific conference “Education and medicine in the era of globalization, national and international experience”. 2014; 85-86.

Protsenko GA, Kashuba OV. Comparative features of side effects caused by NSAIDs diclofenac and nimesulide – the problem of clinical pharmacology in rheumatology. Ukrainskyi medychnyi chasopys. 2011; 4(46): 68-76.

Matveeva OV, Chekman IS, Nalotov SV et al. Pharmacovigilance and approaches to its implementation, guidance. Ministry of Health of Ukraine, Ministry of Health of Ukraine, Ukrmedpatentinform. Kyiv. 2013; 85.

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