Role of Clinical and Genealogical Analysis of Genealogical Trees in the Gynaecologist’s Practice

O. V. Paliychuk

Abstract


The results of medical-genetic counselling introduction are presented in the article basing on the results of the questionnaire survey of 750 females during general gynaecological admission in order to reveal the families with tumour pathology aggregation. The analysis of clinical-genealogical data of the females from such families determined that malignant tumours association in their families corresponded to familial cancer syndrome (Lynch syndrome II) or hereditary cancer. Basing on the results of complex clinical examination of 73 probands who had malignant tumours aggregation in their genealogical trees, malignant and premalignant processes in female reproductive system organs were detected. The obtained data indicated the effectiveness and reasonability of questionnaires as a simple screening method during gynaecological admission to reveal the families with tumour pathology accumulation and to plan further extended individual examination for females from such families aiming on timely detection and treatment of benign pathology of female reproductive system organs and cancer development prevention.

Keywords


cancer of female reproductive system organs; genealogical tree; familial cancer syndrome; medical-genetic counselling

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References


Vovk IB, Kornatskaya AG, Khominskaya ZB. Endocrine homeostasis status in women with benign ovarian space-occupying lesions in the process of treatment. Pediatria, akusherstvo i hinekolohiia. 2006; 3: 143-147.

Ashrafian LA, Kiselev VI. Tumors of reproductive organs (etiology and pathogenesis). Moscow: Publishing house Dimitrage Graphic Group. 2007; 216.

Kitsera NI, Shparyk YaV, Bilynskiy BT, Tril OV. Analysis of the mutations in the genes BRCA1/2 in patients with familial/hereditary cancer of mammary gland, living in Lviv Oblast (Ukraine). Oncolohiia. 2012; 11: 44-49.

Osinskiy SP, Gluzman DF, Kliff Y, et al. Molecular diagnostics of tumors. Kiev. 2007; 246.

Chekhun VF. Modern state and perspectives of fundamental research in experimental and clinical oncology. Oncolohiia. 2010; 12 (3): 219-223.

Imianitov EN, Khanson KP. Molecular oncology: clinical aspects. Saint-Petersburg: Publishing house SPbMAPO. 2007; 211.

Girolimetti G, Perrone AM, Santini D, et al. BRCA-associated ovarian cancer: from molecular genetics to risk management. Biomed Res Int 2014; doi: 10.1155/2014/787143.

Sekine M, Yoshihara K, Tanaka K. Clinical aspects of familial ovarian cancer - current status and issues in Japan. Gan To Kagaku Ryoho 2012; 39(4): 506-11.




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