AbstractRegularities of changes in basic physiological, biophysical and immune and metabolic properties of oral fluid were discovered at the stages of comprehensive treatment of 147 patients with inflammatory diseases of maxilla-facial area (ID MFA). At the stages of clinical monitoring (CM) of patients with ID MFA biophysical properties of oral fluid (OF) were characterized by significant differences. The support of acid-alkali condition of oral cavity was provided by decrease in OF buffering capacity (by 25.0%), decrease in oral fluid pH (by 17.0%) on the background of the increase in its viscosity (by 23.0%) and almost twofold increase in saliva flow rate. The changes were accompanied by a decrease in the relative level and absolute measures of urease microbial enzyme activity by 2.5 times. Significant reduction of OC microbial content was detected being indicated by changes in absolute and relative urease activity corresponding to the first subclinical compensated stage. OF lysozyme activity was characterized by decrease in indices at the late and remote postoperative period and changes in secretory immunoglobulin SIGA levels were characterized by reverse regularity. Indicators of OF antioxidant defense (AOD) enzymatic chain were characterized by increased activity of superoxide dismutase (SOD) (at an early period) and reduced glutathione and catalase at the remote period. Bioenergetic state of buccal epithelium differed in patients with ID MFA depending on the treatment stage. The formation of its defined disadaptive types occurred. Their significance and frequency depended on the psychophysiological addictive state.
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