Efficacy of Microelements, Antioxidants and Nitric Oxide Donators Use for the Correction of NO-Synthase System in the Myocardium of Rats with Hypothyroid Dysfunction on the Background of Combined Iodine and Selenium Deficiency

L. V. Nykolyshyn, N. M. Voronych-Semchenko, S. M. Voronych, N. S. Storozhuk

Abstract


The performance of NO-synthase system in the myocardium of rats with iodine deprivation, on the background of combined iodine and selenium deficiency and under conditions of iodine correction (potassium iodide); iodine and selenium (potassium iodide, selenium active); iodine, selenium, antioxidants, donators of NO (potassium iodide, selenium active, a-tocopherol acetate, L-arginine hydrochloride) was analyzed in the article. The development of hypothyroid dysfunction was detected to be accompanied by inhibition of NO-synthase system in the myocardium, mainly through inducible NOS. Potassium iodide and selenium active had positive influence on the metabolism of nitric oxide in the myocardium. This could be the result of restoration of thyroid gland functional capacity. The introduction of a-tocopherol acetate and L-arginine hydrochloride was accompanied by increase in constitutive NOS activity. Comparative analysis of experimental research on the capabilities of hypothyroid dysfunction correction on the background of microelements imbalance using potassium iodide, simultaneous administration of selenium and potassium iodide, involving a-tocopherol acetate and L-arginine hydrochloride to the scheme of correction confirms the importance of individual approach to the prevention and correction of thyroid disease manifestations.


Keywords


iodine deficiency; selenium deficiency; NO-synthase system; cardiovascular system

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References


Barysheva ES. The role of microelements in functional and structural homeostasis of thyroid gland. Mizhnarodnyy endokrynologichnyy zhurnal. 2010; 7: 15–25.

Gunko IP. Folic acid and vitamin complex of А, В1, В6 and selenium as means of correction the toxic affects of methotrexate. Likarska toksykolohiia. 2003; 3: 6–12.

Zubkova ST. The estimation of the state of vessels endothelial function in patients with hypothyroidism. Endokrynolohiia. 2011; 16 (1): 49–54.

Kileinikov DV. The pathogenesis of arterial hypertension in patients with primary hypothyroidism. Klinichna medytsyna. 2009; 5: 30–32.

Kikhtyak OP. The changes of carbohydrates and lipids metabolism in patients with hypothyroid syndrome. Visnyk naukovykh doslidzhen. 2012; 2: 27–28.

Kulmatyckyy AV. Nitric oxide and peroxide oxidation of lipids in acute period of repeated ischemic stroke. Klinichna ta eksperymentalna patolohiia. 2011; Х (4): 49–56.

Kulchyckyy OK. The system of nitric oxide and age. Bukovynskyi medychnyi visnyk. 2005; 9(2): 143–144.

Mitchenko OI. The atherosclerosis of coronary arteries in patients with diabetes mellitus and hypothyroidism. Ukrainskyi kardiologichnyi zhurnal. 2013; 5: 71–79.

Nepomnyashykh LM. The structural reactions of myocardium and lipid spectrum of blood serum in case of modeling the hypercholesterolemia and hypothyroidism. Biuleten eksperymentalnoi biolohii i medytsyny. 2013; 155 (5): 647–652.

Oksyuta VM. The examination of lipid metabolism in female with disturbances of reproductive function and hypothyroidism. Bukovynskyi medychnyi visnyk. 2012; 16 (4): 120–123.

Romanyuk AM. Spermatogenic function in conditions of heavy metals action and correction by “Tivortin”. Likarska sprava. 2012; 1–2: 123–128.

Tuchak OI. The state of lipid peroxidation system in conditions of correction the hypothyroidism by α–tocopherole. Aktualni problemy suchasnoi medycyny. Visnyk Ukrainskoi stomatolohichnoi akademii. 2009; 4(28): 143–146.

Charnosh SМ. Comparative characteristics of three experimental models of hypothyroidism. Visnyk naukovykh doslidzhen. 2007; 2: 113-115.

Fairweather–Tait SJ. Selenium bioavailability current knowledge and future research requirements. Am J Clin Nutr. 2010; 91 (14): 84–91.

Gaertner R. Selenium and thyroid hormone axis in critical ill states: An overview of conflicting view points. 2009; 23: 71–74.

Martinez–Galan JR. Early effect of iodine deficiency on radial glial cells of the hippocampus of the rat fetus. J. Clin. Invest. 1997; 99: 2701–2709.




Copyright (c) 2017 L. V. Nykolyshyn, N. M. Voronych-Semchenko, S. M. Voronych, N. S. Storozhuk

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