Abnormal Production of Monocyte Chemoattractant Protein in Patients with Primary Hypothyroidism

O. M. Didushko

Abstract


The objective of the research was to study monocyte chemoattractant protein-1 (MCP-1) levels in patients with hypothyroidism.

Materials and methods. 139 patients with manifested hypothyroidism were examined. Among them 69 patients had postoperative hypothyroidism and 70 – developed it on the background of autoimmune thyroiditis. All patient were divided into several groups: IA group involved 35 patients with hypothyroidism resulting from AIT without obesity; IB group included 35 patients suffering from AIT accompanied by hypothyroidism and obesity; IIA group encompassed 34 patients with clinical hypothyroidism without obesity; and IIB group involved patients with clinical hypothyroidism accompanied by obesity, n=35.

Results of the research. Patients’ data showed significantly higher levels of MCP-1 in all groups. Correlative analysis revealed a direct correlation between MCP-1 levels and thyroid stimulating hormone, as well as blood creatinine level and reverse correlation between glomerular filtration rate and MCP-1 concentration highly manifested in people with noncompensated hypothyroidism on the background of autoimmune thyroiditis accompanied by obesity.

Conclusions. Obtained data proved that the level of MCP-1 reflected the functional state of kidneys to some extent and can be used additionally to other conventional methods of patients’ examination.


Keywords


hypothyroidism; thyroid hormones; monocyte chemoattractant protein-1

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