AbstractThe objective of the research was to study monocyte chemoattractant protein-1 (MCP-1) levels in patients with hypothyroidism.Materials and methods. 139 patients with manifested hypothyroidism were examined. Among them 69 patients had postoperative hypothyroidism and 70 – developed it on the background of autoimmune thyroiditis. All patient were divided into several groups: IA group involved 35 patients with hypothyroidism resulting from AIT without obesity; IB group included 35 patients suffering from AIT accompanied by hypothyroidism and obesity; IIA group encompassed 34 patients with clinical hypothyroidism without obesity; and IIB group involved patients with clinical hypothyroidism accompanied by obesity, n=35.Results of the research. Patients’ data showed significantly higher levels of MCP-1 in all groups. Correlative analysis revealed a direct correlation between MCP-1 levels and thyroid stimulating hormone, as well as blood creatinine level and reverse correlation between glomerular filtration rate and MCP-1 concentration highly manifested in people with noncompensated hypothyroidism on the background of autoimmune thyroiditis accompanied by obesity.Conclusions. Obtained data proved that the level of MCP-1 reflected the functional state of kidneys to some extent and can be used additionally to other conventional methods of patients’ examination.
Basu G., Mohapatra A. Interactions between thyroid disorders and kidney disease. Indian J. Endocrinol. Metab. 2012; 16 (2): 204-213.
Lee E. U., Chung C. H., Khoury C. C. [et al.] The monocyte chemoattractant protein-1 / CCR2 loop, inducible by TGF beta, increases podocyte motility and albumin permeability. Amer. J. Physiol. Renal Physol. 2009; 297 (1): 85-94.
Dedov I.I., Melnychenko H.А., Fadieiev V.V. Endocrynology. Manual. Мoscow. Мedia. 2009; 432.
Kaminskii A.I. Diseases of the thyroid gland. Problemy endocrynolohii. 2007; 51 (7): 7-23.
Chiarelli F., Cipollone F., Mohn A. et al. Circulating monocyte chemoattractant protein-1 and early development of nephropathy in type 1 diabetes. Diabetes Care. 2002; 25: 1829-1834.
Carrero J. J., Qureshi A. R., Axelsson J. et al. Clinical and biochemical implications of low thyroid hormone levels (total and free forms) in euthyroid patients with chronic kidney disease. Journal of Internal Medicine. 2007; 262 (6): 690–701.
Choi K. M., Lee J., Lee K.W., Seo J. A. et al. Comparison of serum concentrations of C-reactive protein, TNF-alpha, and IL6 between elderly Korean women with normal and impaired glucose tolerance. Diabetes Res.Clin.Pract. 2004; 64: 99-106.
Petkov Stoyanov, Martin Navarro J.A., Merida Herrero E., Gutierrez Sanchez M.J. Decrease in renal function associated with hypothyroidism. Nephrologia. 2010; 30 (3): 378–380.
Eddy A.A. Progression in chronic kidney disease. Adv. Chronic Kidney Dis. 2005; 12: 353-365.
Wondisford F.E., Radovick S. Clinical Management of Thyroid Disease. Baltimore, Maryland: John Hopkins University School of Medicine. 2009; 860.
Giunti S., Barutta F., Perin P.C., Gruden G. Targeting the MCP-1/CCR2 System in diabetic kidney disease. Curr. Vasc. Pharmacol. 2010; 8(6): 849-860.
Den Hollander J.G., Wulkan R.W., Mantel M.J., Berghout A. Correlation between severity of thyroid dysfunction and renal function. Clin Endocrinol.2005; 62: 423–427.
Vargas F., Moreno J.M., Rodriguez-Gomez I. et al. Vascular and renal function in experimental thyroid disorders. Eur. J. Endocrinol. 2006; 154: 197-212.
Vernon M.A., Mylonas K.J., Hughes J. Macrophages and renal fibrosis. Semin. Nephrol. 2010: 30(3): 302-317.
Meuwese C.L., DekkerF. W., Lindholm B. et al. Baseline levels and trimestral variation of triiodothyronine and thyroxine and their association with Mortality in maintenance hemodialysis patients. Clin. J. Am. Soc. Nephrol. 2012; 7: 131-138.
Salman Razvi. The Influence of Age on the relationship between subclinical hypothyroidism and ischemic heart disease: a metaanalisis. J. Clin. Endocrinol. Metabol. 2008; 9 (8): 59-67.
Tesch G.H. MCP-1/CCL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy. Am. J. Physiol. Renal Physiol. 2008; 294: 697-701.
Malyszko J., Malyszko J. S., Pawlak K., Mysliwiec M. Thyroid function, endothelium, and inflammation in hemodialyzed patients: possible relations? J. Ren. Nutr. 2007; 17 (1): 30–37.
Williams T.M., Little M.H., Ricardo S.D. Macrophages in renal development, injury, and repair. Semin. Nephrol. 2010; 30(3): 255-267.
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