Age-Related Peculiarities of Structural Reorganization of the Hepatic Lobules in Rats


hepatic lobule
sinusoidal capillaries


The liver of intact rats at 12 and 24 months of age was investigated. Histological (hematoxylin and eosin stain and method of Shabadash) and electron microscopy methods were used. As a result of conducted research there was revealed that the hepatic lobule of 12-month-old rat could be divided into three zones: peripheral (Zone I), intermediate (Zone II) and central (Zone III). Hepatocytes of Zone I had well-developed protein-synthesizing apparatus and, probably, carried out the synthesis of glycogen and protein. Hepatocytes of Zone III acted as a depot for glycogen; glycogenolysis occurred there. Senile changes in the hepatic parenchymal cells were observed including destructive changes in the protein-synthesizing apparatus and mitochondria, the accumulation of cytoplasmic lipid droplets. With age, there was a violation of the microcirculation including age-related dystrophic changes in endoteliocytes, a significant decrease in the number of their pores and fenestrae, pericapillary sclerosis and distention of spaces of Disse. Such changes led to the deterioration of the transendothelial exchange and the development of dystrophic changes in hepatocytes


Berezovskyi V.Ya., Yanko R.V., Litovka I.H. The effect of alimentary deprivation on physiological regeneration of the liver parenchyma in young and mature rats. Fiziolohichnyi zhurnal. 2008; 54(6): 66-71.

Bolotna I.V. The influence of the hyperhydrational disorders of water-salt metabolism of organism on the morphology of the liver in senile rats. Ukraiinskyi morfolohichnyi almanakh. 2009; 7(2): 16-18.

Lutsyk O.D., Herashchenko S.B., Dieltsova O.I. The use of new list of international terms relating to human histology in morphology and clinic of digestive tract. Liky Ukraiiny. 2012; 1(3-4): 5-8.

Dieltsova O.I., Skrypko V.D., Honchar M.H. Ultrastructural changes of the liver in experimental small bowel obstruction during the course of treatment. Naukovyi visnyk Uzhhorodskoho universytetu, seriia “Medytsyna”. Uzhorod. 2014; 1(49): 65-71.

Karpezo N.O., Hurniak O.M., Lynchak O.V. Features of morphological and functional changes in the liver of rats under the influence of a potential anticancer drug derived from dihydro-pyrrol compared to conventional drug - 5-fluorouracil. Visnyk problem biolohii ta medytsyny. 2011; 10(2): 100-103.

Lynchak O.V. Morphological changes in the liver of rats under the influence of maleimide on the background of chemotherapy-induced colon cancer. Biolohichni studii. 2013; 7(1): 41-54.

Yakushko O.S., Shepitko V.I., Yeroshenko H.A. et al. Method of polychrome staining of histological specimens. Svit medytsyny ta biolohii. 2013; 3: 61-64.

Makar B.H., Protsak T.V., Haiina N.I. et al. The role of the liver in the maintaining human homeostasis under normal and pathological conditions. Visnyk problem biolohii ta medytsyny. 2012; 1(3): 15-17.

Sohuiko Yu.R. Morphological features of the liver in rats under normal conditions and in experimental diabetes mellitus during early stages of the disease. Ukraiinskyi morfolohichnyi almanakh. 2012; 10(2): 137-140.

Sohuiko Yu.R. Dynamics of the ultrastructural features of the liver in rats under normal conditions and in experimental diabetes mellitus during early stages of the disease. Eksperymentalna ta klinichna fiziolohiia i biokhimiia. 2010; 4: 12-19.

Zafar M., Naeem-Ul-Hassan Naqvi S., Ahmed M. et al. Altered liver morphology and enzymes in streptozotocin induced diabetic rats. Int. J. Morphol. 2009; 27(1): 719 - 725.

Ashraf Y. N. Morphological, biochemical, histological, and ultrastructural protective effects of misoprostol on cisplatin induced-hepatotoxicity in adult male rats. Saudi Med. Journal. 2013; 34(12): 1237–1247.

Baratta J. L., Ngo A., Lopez Br. et al. Cellular Organization of Normal Mouse Liver: A Histological, Quantitative Immunocytochemical, and Fine Structural Analysis. Histochem. Cell Biol. 2009; 131(6): 713–726.

Noorafshan A., Esmail-Zadeh B., Bahmanpour S. et al. Early stereological changes in liver of Sprague-Dawley rats after streptozotocin injection. Indian Journal of Gastroenterology. 2005; 24: 104–107.

Golalipour M. J., Ghafari S. Quantitative studies of Hepatocytes in Periportal and Perivenous zones of the liver lobules in diabetic Rats. International Journal of Zoological Research. 2007; 3(4): 186–192.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.


Download data is not yet available.