AbstractMandatory component of burn disease treatment is detoxification therapy: intravenous infusion of medicines with rheological and antishock effects.The objective of the research was to establish morphological signs of damage and compensatory-adaptive changes in rat spleen on the 14th, 21st and 30th days after II–III degree skin burn and manifestations of damage correction resulting from the use of integrated infusions of colloid-hyperosmolar solutions of lactoprotein in combination with sorbitol.Material and methods. Experimental studies of burn injury were made on 56 nonlinear rats of both sexes weighing 150-170 g. Group I (the control group - 8 animals) included rats without burns receiving intravenous infusion of a 0.9 % NaCl solution at a dose of 10 ml/kg into inferior vena cava for 5-6 minutes. Group II (24 animals) included rats with skin burns receiving intravenous infusion of a 0.9% NaCl solution at a dose of 10 ml/kg into inferior vena cava for 5-6 minutes. Group III (24 animals) included rats with skin burns receiving intravenous infusion of a solution of lactoprotein in combination with sorbitol at a dose of 10 ml/kg into inferior vena cava for 5-6 minutes.Results. During the pilot study it was proved that in rats with skin burn injury, which were injected with a solution of lactoprotein in combination with sorbitol, dystrophic and destructive changes in the spleen were less expressed compared to rats injected with a 0.9% NaCl solution.Conclusions. Lactoprotein in combination with sorbitol in case of thermal injury manifests adaptogenic properties of increasing pathogenicity of both extended periarterial areas and boundary zones; multiplication and hypertrophy of reticular cells.
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