AbstractPremenstrual syndrome (PMS) is one of the most common neuroendocrine disorders in gynecology. Both social and medical factors are important in the development of this pathology. Objective of the research was to study characteristics of the reproductive system in women with PMS. Material and methods. The research included 200 women of reproductive age with diagnosis of PMS. R. Moos Menstrual Distress Questionnaire was used for diagnosis of this pathology. Women kept a diary of introspection during 2-3 menstrual cycles. Control group consisted of 50 women without diagnosis of PMS. Results of the study. We found no differences in the formation and nature of menstrual function between women with PMS and healthy women. High frequency of gynecological pathology was observed in both groups – over 90%. Inflammation of the upper genital tract dominated in the structure of gynecological morbidity. However, patients with PMS had a significantly greater frequency of such inflammatory diseases compared with healthy women (c2=6.60, p=0.01, OR=2.61, 95% CI 1.30-5.22, p=0.007). Women with PMS also set a tendency towards a higher frequency of lower genital tract inflammation (χ2=1.37, p=0.24, OR=1.52, 95% CI 0.82-284, p=0.18). Background and precancerous diseases of the female genital organs occurred in 1.49 times more in these patients than in healthy women (c2=4.78, p=0.03, OR=2.12, 95% CI 1.12-4.00, p=0.03). The spread of mastopathy was significantly higher in 2.69 times in patients with PMS (c2=11.30, p<0.001, OR=3.96, 95% CI 1.77-8.87, p<0.001), which was especially characteristic for women with edematous and cephalgic forms of the disease. Conclusion. Thus, inflammatory processes of female genital organs can be considered as risk factors in premenstrual syndrome development.
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