THE EFFECT OF IVABRADINE AND OMEGA-3 POLYUNSATURATED FATTY ACIDS ON INNATE IMMUNITY IN PATIENTS WITH HEART FAILURE
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Keywords

heart failure
treatment
ivabradine
ω-3 PUFA
NT-proBNP

Abstract

Heart failure (HF) is a major public health issue with a current prevalence of over 5.8 million in the USA and over 23 million worldwide. Ischemic heart disease is known to be the most important risk factor for HF. Ivabradine is a new therapeutic agent designed to reduce heart rate at rest and during exercise by selective inhibition of a novel receptor (If channel) located on the pacemaker-cell membrane within the sinoatrial node.  As such, ivabradine joins a list of rate-limiting medications already available to prescribers for the control of heart rate in coronary artery disease (CAD) and HF with systolic dysfunction.  The ω-3 polyunsaturated fatty acids (PUFA), such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are used for HF treatment. The objective of the research was to evaluate the dynamics of innate immunity parameters in patients with ischemic HF by treatment with ivabradine and ω-3 polyunsaturated fatty acids. Material and Methods. 357 patients with ischemic HF and preserved sinus rhythm were observed. All the patients were divided into four groups according to their treatment. Physical examinations were performed. The functional activity of neutrophils and lymphocytes was examined. Conclusions. All used therapeutic schemes influenced unstimulated activity of lymphocytes only, which was caused by normalization of the general condition and some decline in inflammation. 
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