EXPERIMENTAL TREATMENT OF ACUTE INTERSTITIAL PANCREATITIS USING LOCAL HYPOTHERMIA

M. H. Honchar, D. M. Vynnyk

Abstract


Acute interstitial pancreatitis (AIP) is one of the simplest forms of acute pancreatitis treated conservatively in most cases. However, AIP transforms into destructive forms of acute pancreatitis when treating inadequately (15% of cases). The mortality rate for patients with acute interstitial pancreatitis is 1.6-3.1% while the mortality rate for patients with its destructive forms reaches 80%.

Materials and Methods. Local hypothermia (LGP) of pancreas by using 0.9% NaCl solution with an initial temperature of 4 °C was performed experimentally on 60 white rats after modeling of AIP. The enzymatic activity in the pancreas and the level of inflammatory mediators before and after the application of LGP were investigated.

Results. The use of LGP in experimental rats with AIP reduced the level of alpha-amylase by 3.2 times and decreased levels of interleukin 6 by 2.3 times.

Conclusions. It was revealed that the activity of the inflammatory process reduced gradually after application of local hypothermia for 8-10 hours. It can be explained by the inhibition of the cascade of enzymatic reactions and decrease in the synthesis of active enzymes, and significantly slower metabolic processes of the pancreas.

Keywords


pancreas; local hypothermia; acute interstitial pancreatitis

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