Thrombophilia as a Risk Factor for Thrombosis
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Keywords

thrombophilia
venous thrombosis
arterial thrombosis
anticoagulant therapy

Abstract

The review article presents a contemporary view on the most common causes of hereditary and acquired thrombophilias and their role in the development of venous and arterial thromboses. The examination of patients in accordance with modern requirements consists in determining the causes and risk factors for blood clot formation, as well as implementing secondary prevention of recurrent thrombosis. Analysis of genetic and acquired hemostatic disorders allows us to identify a group of patients who require long-term anticoagulant therapy and mandatory anticoagulant prophylaxis in cases involving a high risk of thromboembolic complications.

https://doi.org/10.21802/gmj.2020.1.5
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References

Bokarev IN, Popova LV. What are thrombophilias to-day? Clinical Medicine. 2013;91(12):4-9. [published in Russian]

Akinshina SV, Makatsariya AD. Thrombosis of unusual sites and thrombophilia. Obstetrics, Gynecology and Reproduction. 2014;8(2):97-111. [published in Russian]

Pizova NV. Trombofiliyi: geneticheskiye polimorfizmy i sosudistyye katastrofy. Moscow: IMA-PRESS; c2013. 248p.

Pribylov SA, Pribylova NN, Alfimova OS et al. A clinical case of congenital and acquired thrombophilia with pulmonary artery thrombosis. Russian Pulmonology. 2017;27(3):423-426. DOI: https://doi.org/10.18093/0869-0189-2017-27-3-423-426

Fazliakhmetova AG, Bogdanov EI. Thrombophilia and stroke. Practical Medicine. 2016;4-2(96):133-136. [published in Russian]

Akbayrak H, Tekumit H. Pulmonary thromboendarterectomy in a combined thrombophilia patient. Cardiovasc J Afr. 2019;30(1):e4-e6. DOI: https://doi.org/10.5830/CVJA-2018-052 [PMid:30460973]

Bergavist D, Svensson PJ. Treatment of Mesenteric Vein Thrombosis. Semin Vasc Surg. 2010;23(1):65-68. DOI: https://doi.org/10.1053/j.semvascsurg.2009.12.008 [PMid:20298951]

Chu A, Aung TT, Arumugam MS et al. A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia. Case Rep Hematol. 2018;2018:9098604. DOI: https://doi.org/10.1155/2018/9098604 [PMid:30363672 PMCid:PMC6180927]

Cushman M, Tsai AW, White RH et al. Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology. Am J Med. 2004;117(1):19-25. DOI: https://doi.org/10.1016/j.amjmed.2004.01.018 [PMid:15210384]

Dugalić S, Petronijevic M, Stefanovic A et al. The association between IUGR and maternal inherited thrombophilias: A case-control study. Medicine (Baltimore). 2018;97(41):e12799. DOI: https://doi.org/10.1097/MD.0000000000012799 [PMid:30313110 PMCid:PMC6203511]

Favaloro EJ. Danger of false negative (exclusion) or false positive (diagnosis) for 'congenital thrombophilia' in the age of anticoagulants. Clin Chem Lab Med. 2019;57(6):873-882. DOI: https://doi.org/10.1515/cclm-2018-1041 [PMid:30485173]

Green D. Thrombophilia and Stroke. Topics in stroke rehabilitation. 2003;10(3):21-33. DOI: https://doi.org/10.1310/L9KD-N5N8-69X0-08QK [PMid:14681817]

Hu Y, Yu Y, Bu Z et al. Increased systemic heparanase in retinal vein occlusion is associated with activation of inflammation and thrombophilia. Retina. 2018; DOI: https://doi.org/10.1097/IAE.0000000000002374

Kucher N. Clinical practice. Deep-vein thrombosis of the upper extremities. N Engl J Med. 2011;364(9):861-869. DOI: https://doi.org/10.1056/NEJMcp1008740 [PMid:21366477]

Martinelli I, De Stefano V. Rare thromboses of cerebral, splanchnic and upper-extremity veins. A narrative review. Thromb Haemost. 2010;103(6):1136-1144. DOI: https://doi.org/10.1160/TH09-12-0873 [PMid:20352171]

Wu O, Robertson L, Langhorne P et al. Oral contraceptives, hormone replacement therapy, thrombophilias and risk of venous thromboembolism: a systematic review. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study. Thromb Haemost. 2005;94(1):17-25. DOI: https://doi.org/10.1160/TH04-11-0759 [PMid:16113779]

Skeith L. Anticoagulating patients with high-risk acquired thrombophilias. Blood. 2018;132(21):2219-2229. DOI: https://doi.org/10.1182/blood-2018-05-848697 [PMid:30463994]

Tan MKH, Onida S, Laffan M, Davies AH. Thrombophilia in non-thrombotic chronic venous disease of the lower limb - a systematic review. Br J Haematol. 2018;183(5):703-716. DOI: https://doi.org/10.1111/bjh.15692 [PMid:30488425]

Torrealba JI, Osman M, Kelso R. Hypercoagulability predicts worse outcomes in young patients undergoing lower extremity revascularization. J Vasc Surg. 2019;70(1):175-180. DOI: https://doi.org/10.1016/j.jvs.2018.09.062 [PMid:30583891]

Vossen CY, Rosendaal FR, EPCOT Study Group. Risk of arterial thrombosis in carriers of familial thrombophilia. J Thromb Haemost. 2006;4(4):916-918. DOI: https://doi.org/10.1111/j.1538-7836.2006.01838.x [PMid:16634772]

Wu O, Robertson L, Twaddle S et al. Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study. Health Technol Assess. 2006;10(11):1-110. DOI: https://doi.org/10.3310/hta10110 [PMid:16595080]

Van der Hagen PB, Folsom AR, Jenny NS et al. Subclinical atherosclerosis and the risk of future venous thrombosis in the Cardiovascular Health Study. J Thromb Haemost. 2006;4(9):1903-1908. DOI: https://doi.org/10.1111/j.1538-7836.2006.02096.x [PMid:16961598]

Zakai NA, Katz R, Jenny NS et al. Inflammation and hemostasis biomarkers and cardiovascular risk in the elderly: the Cardiovascular Health Study. J Thromb Haemost. 2007;5(6):1128-1135. DOI: https://doi.org/10.1111/j.1538-7836.2007.02528.x [PMid:17388967]

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