AbstractThe objective of the research was to study the effectiveness of course application of magnesium and calcium-containing drugs on the background of conventional therapy on the changes in the content of macronutrients in red blood cells and the activity of matrix metalloproteinase - 9 in the patients with a co-existence of undifferentiated connective tissue disease and gastroesophageal reflux disease. Materials and Methods. All 75 patients with gastroesophageal reflux disease associated with undifferentiated connective tissue disease were divided into three groups: Group I included 25 patients who received Magne-B6 at a dose of 2 tablets 3 times a day in addition to the standard background therapy with “Panocid” at a dose of 40mg once a day; Group II comprised 25 patients who received “Ca-D3 Nycomed” at a dose of 1 tablet 3 times a day in addition to the standard background therapy; Group III included 25 patients who received a combination of “Magne-B6” and “Ca-D3 Nycomed” in addition to the standard background therapy. Results. In Group I, the proposed complex therapy resulted in a significant increase in Mg2+ by 40.9%. Mg2+ dynamics was less significant in Group II; this index reached the level of 17.9 ± 2.04 µg/g (р"˃0.05); in its turn, Ca2+ level increased to 80.6 ± 2.12 μg/g (p"<0.05) in these patients. Mg2+ and Ca2+ indices showed the most significant positive dynamics in Group III: 21.52 ± 2.47 μg/g (р"<0.05) and 102.7±1.37 µg/g, respectively. After combination treatment, we traced the dynamics of changes in the level of matrix metalloproteinase - 9: it decreased by 39.45% in Group I, by 35.3% in Group II, by 53.18% in Group III and reached the level of 1689.266 ± 14.89 pg/ml, approaching the indicators of the control group. Сonclusions. Based on the data obtained, it can be argued that simultaneous addition of “Magne-B6” and “Ca-D3 Nikomed” to the standard therapy for gastroesophageal reflux disease in the patients with undifferentiated connective tissue disease contributed to a significant decrease in the level of matrix metalloproteinase-9 resulting in reduced degradation and increasing synthesis of new connective tissue components.
Shilov AM, Melnik MV, Sviridova AYu. Displaziya soyedinitelnoy tkani i defitsit magniya. Farmateka. 2010; 20(213): 35-38.
Blancquaert L, Vervaet C, Derave W. Predicting and Testing Bioavailability of Magnesium Supplements. Nutrients. 2019;11(7):E1663. DOI: https://doi.org/10.3390/nu11071663 [PMid:31330811 PMCid:PMC6683096]
Faizullin OV, Bezkrovna KS, Shulga LI. Functional interaction of the elemental balance in the human body and the digestive system. Zb. nauk. prats spivrobit. NMAPO imeni P. L. Shupyka. 2019;33:63-73. [Published in Ukrainian].
Prudenko MYu, Bodnia AA, Yarmysh NV. Biolohichna rol kaltsiiu ta tsynku v rehuliatsii funktsii y rozvytku zakhvoriuvan systemy travlennia. Aktualnyye problemy eksperimentalnoy i klinicheskoy biokhimiyi: materialy VI Mezhvuz. nauch.-prakt. konf. s mezhdunar uchastiyem. Kharkiv: KhNMU; c2017. 91-92.
Nechayeva GI, Drokina OV, Druk IV et al. Main approaches in treatment of patients with connecting tissues dysplasia. Attending Doctor. 2014;8:54-56. [Published in Russian]
Gnusaev SF, Apenchenko YuS, Rozov DN. Vzaimosvyaz gastroezofagealnogo reflyuksa i priznakov displaziyi soyedinitelnoy tkani u detey i podrostkov. Posobiye dlya vrachey. Moscow. c2004. 20p.
Akata T. Cellular and molecular mechanisms regulating vascular tone. Part 1: basic mechanisms controlling cytosolic Ca2+ concentration and the Ca2+"dependent regulation of vascular tone. J Anesth. 2007;21:220-231. DOI: https://doi.org/10.1007/s00540-006-0487-5 [PMid:17458652]
Bychkov MA, Yakhnytska MM. Osoblyvosti vmistu elektrolitiv u shlunkovomu soku khvorykh na hastroezofahalnu refleksnu khvorobu. Ukraine. Nation's Health. 2016;1-2(37"38):16-18.
Marushko IuV, Аsonov АО, Hyschak TV. The role of magnesium in humans and the effect of reduced magnesium on the quality of life of children with gastro esophageal reflux disease. Sovremennaya Pediatriya. 2019;1(97):124-130. [Published in Ukrainian] DOI: https://doi.org/10.15574/SP.2019.97.124
Kens KA, Lukyanenko NS, Nakonechnyi AY et al. Substantiation of treatment tactics in young children with congenital malformations associated with undifferentiated connective tissue dysplasia. Paediatric Surgery. 2017; 4(57):80-84. [Published in Ukrainian] DOI: https://doi.org/10.15574/PS.2017.57.80
Ahvazi B, Boeshans KM, Rastinejad F. The emerging structural understanding of transglutaminase 3. J Struct Biol. 2004;147(2):200-207. DOI: https://doi.org/10.1016/j.jsb.2004.03.009 [PMid:15193648]
Ahvazi B, Boeshans KM, Idler W et al. Roles of calcium ions in the activation and activity of the transglutaminase 3 enzyme. J Biol Chem. 2003;278(26):23834-23841. DOI: https://doi.org/10.1074/jbc.M301162200 [PMid:12679341]
Tvorogova TM, Vorobyeva AS. Nedifferentsiirovannaya displaziya soyedinitelnoy tkani s pozitsiyi diselementoza u detey i podrostkov. RMZh. 2012;4:12-15.
Ismail AA, Ismailn NA. Magnesium: A mineral essential for health yet generally underestimated or even ignored. J Nutr Food Sci. 2016;6:4. DOI: https://doi.org/10.4172/2155-9600.1000523
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.