Level of Osteotropic Elements in the Jaw Bones of Experimental Animals in Terms of the Impact of Xenobiotics
PDF

Keywords

intact animals
cadmium intoxication
nitrite intoxication
nitrite-cadmium intoxication
macro- and microelements
bone tissue

Abstract

Pollution of the environment with heavy metals, pesticides, nitrates leads to an unceasing deterioration of the population’s health, in particular, the dental one. Excessive intake of salts of heavy metals and nitrites is accompanied by changes in calcium-phosphorus metabolism rates, indicating a disorder of metabolic processes in bone tissue. This necessitates the study of the level of osteotropic elements of the jaw bone tissue. Materials and methods of research. In the experiment on 80 white outbred male rats, the effects of cadmium chloride, sodium nitrite and their combined action on the content of osteotropic elements in the jaw bone were studied. The control group consisted of 10 intact animals. Results. It was determined that in the dynamics (1st, 14th, 28th days) of both cadmium-nitrite, nitrite and cadmium intoxication there was observed the accumulation of cadmium and decrease of calcium, copper, zinc levels in bone tissue of animal jaws compared to intact group. Conclusions.The most significant changes in the level of osteotropic elements in the jaw bones are found in the combined effect of xenobiotics, which is important for understanding of the metabolic processes in the oral cavity.
https://doi.org/10.21802/gmj.2019.2.13
PDF

References

Arustamian OM, Tkachyshyn VS, Aleksiychuk OY. Influence of cadmium compounds on human organism. Medytsyna nevidkladnykh staniv. 2016; 7:109-114. DOI: https://doi.org/10.22141/2224-0586.7.78.2016.86103

Hordiyenko VV. Peculiarities of accumulation of cadmium in the organisms of rats of different ages for prolonged exposure of metal salts in doses of low intensity.Klinichna ta eksperymentalna patolohiya. 2015; XIV(1): 40-43.

Hordiyenko VV, Kosuba RB. Age peculiarities of ecologically conditioned accumulation of heavy metals in organs of intact laboratory rats.Klinichna ta eksperymentalna patolohiya. 2016; XV(3): 26-29.

Ersteniuk HM, Herashchenko SB, Khopta NS. Effect of cadmium chloride and sodium nitrite on the structural and metabolic processes in bone tissue.Dosiahnennia biolohiyi ta medytsyny. 2011; 2:40-45.

Kondratiuk VA, Lototska OV, Flekey NV. Combined action of sodium and cadmium in conditions of acute sanitary-toxicological experiment. Dovkillia ta zdorovyya. 2010; 1: 26-29.

Nechitaylo LY, Khopta NS. Influence of cadmium intoxication on bioelement composition of tissues and organs of experimental animals. Medychna i klinichna khimiya. 2011 (4): 210. Materials of the scientific and practical conference "Biochemical bases of pathogenesis of defeat of internal organs of different etiology and ways of their pharmacological correction" [3-4 November, 2011, Ternopil].

Ostapyak IZ. Peculiarities of clinical and biochemical picture in patients with generalized periodontitis under the influence of eco-pollution by heavy metal salts.Halytskyy likarskyy visnyk.2008; 15(2):58-59.

Smoliar VI, Petrashenko HI. The content of cadmium in food products and rations and its toxicity. Problemy kharchuvannia. 2010; 1-2: 28-31.

Trahtenberg IM, Kolesnikov VS, Lukovenko VP. Heavy metals in the environment.Minsk: Nauka i tekhnika. 1994; 285.

Khopta NS, Ersteniuk HM. Effect of sodium nitrite intoxication on metabolic processes in bone tissue of experimental animals. Materials of the scientific and practical conference with international participation. Babenkivske chytannia; [29-30 October, 2009, Iwano-Frankiwsk]; 55-56.

Khopta NS, Ersteniuk HM. Condition of the mineral matrix of bone tissue of experimental animals under conditions of combined effects of xenobiotics.Medychna khimiya. 2009;11(4):124-127.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Downloads

Download data is not yet available.