AbstractPollution of the environment with heavy metals, pesticides, nitrates leads to an unceasing deterioration of the population’s health, in particular, the dental one. Excessive intake of salts of heavy metals and nitrites is accompanied by changes in calcium-phosphorus metabolism rates, indicating a disorder of metabolic processes in bone tissue. This necessitates the study of the level of osteotropic elements of the jaw bone tissue. Materials and methods of research. In the experiment on 80 white outbred male rats, the effects of cadmium chloride, sodium nitrite and their combined action on the content of osteotropic elements in the jaw bone were studied. The control group consisted of 10 intact animals. Results. It was determined that in the dynamics (1st, 14th, 28th days) of both cadmium-nitrite, nitrite and cadmium intoxication there was observed the accumulation of cadmium and decrease of calcium, copper, zinc levels in bone tissue of animal jaws compared to intact group. Conclusions.The most significant changes in the level of osteotropic elements in the jaw bones are found in the combined effect of xenobiotics, which is important for understanding of the metabolic processes in the oral cavity.
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