AbstractThe objective of the research was to identify the spectrum of complications in women with chronic urogenital chlamydial infection. Materials and methods. There were examined 128 women with chronic inflammatory diseases of genital organs at the age of 16-40 years who were diagnosed with urogenital chlamydial infection and 25 apparently healthy women. In both women with chlamydial infection and healthy ones, urogenital chlamydial infection was diagnosed based on the data of clinical examination and the results of laboratory tests (the identification of chlamydial morphological structure on the pathologic specimens stained according to the Romanowsky-Giemsa method; the identification of chlamydial antigens using the direct immunofluorescence technique; the study of Chlamydia trachomatis antibody titers using the enzyme-linked immunosorbent assay). Results. According to the results of our study, chlamydiae were the most common causes of inflammatory lesions of the urogenital organs in women of different ages leading to different reproductive complications and affecting females mostly at the age of 21-30 years. In women of Group I and Group II, chronic chlamydial disease was detected; disease duration ranged from 6 months to more than 2 years. Miscarriages, infertility (primary, secondary), ectopic pregnancy (tubal, ovarian) were the severest and the most numerous reproductive complications in the examined patients. Conclusion. Chronic chlamydial infection is the most common disease of the female urinogenital organs leading to a wide spectrum of complications including infertility (primary, secondary), miscarriages, ectopic pregnancy (tubal, ovarian), chronic abdominal pain, sexual dysfunction (low libido, hypo/anorgasmia, painful intercourse, neurotic symptoms).
Kiyanskaya YeS, Savitskaya IL, Khamandyak YuV et al. Opyt primineniya dzhozamitsina (vilprafena) v lecheniyi khlamidiynykh i smeshannykh infektsiy urogenitalnogo trakta. Tez. 2-go Foruma meditsiny i krasoty NADK.- Moscow. 2013.
Mavrov GI, Ivashchenko LV, Shcherbakova YuV, Orlova KS. Clinical and epidemiological features of urogenital chlamydia today. Dermatologiya ta venerologiya. 2014;1(63):59-68. [published in Russian]
Mavrov GI, Shcherbakova YuV, Chinov GP. The treatment of complicated chlamydial infection with azithromycin (Sumamed) using in combination with pathogenetic therapy. Ukraiinskyi zhurnal dermatolohii, venerolohii, kosmetolohii. 2010;3(38):123-127. [published in Russian]
Martynenko LV. Suchasni mozhlyvosti diahnostyky ta likuvannia khlamidiinoii infektsii. Zhinochyi likar. 2007;3:20.
Shamina GYe, Akovbyan GV, Kompasova OV. Azitromitsin (zimaks) v terapiyi nekotorykh infektsiy, peredayushchikhsya polovym putom. Vestnik dermatol. i venerol. 2000;1:68.
Mavrov II. Polovyye bolezni: Rukovodstvo dlya vrachey, internov i studentov. Kharkiv: FAKT; c2002. 789p.
Protokol vedeniya bolnykh "Infektsiyi, peredavayemyye polovym putem. Urogenitalnaya khlamidiynaya infektsiya". Kisina VI, editor. Moscow: Nyudiamed; c2011. 164-191.
Rossiyskoye obshchestvo dermatovenerologov. Infektsiyi, peredavayemyye polovym putem. Klinicheskiye rekomendatsiyi. Dermato-venerologiya. Kubanov AA, editor. Moscow: DEKS-Press; c2010. 413-425.
Pogodin OK. Khlamidiynaya infektsiya v akusherstve, ginekologiyi i perinatologiyi: Ucheb. Posobiye. Petrozavodsk: IzdHvo PetrGU; c1997. 168p.
Macaluso M, Wright-Schnapp TJ, Chandra A et al. A public health focus on infertility prevention, detection, and management. Fertil Steril. 2010;93(1):16.e1-10. DOI: https://doi.org/10.1016/j.fertnstert.2008.09.046
Land JA, Van Bergen JE, Morré SA, Postma MJ. Epidemiology of Chlamydia trachomatis infection in women and the cost-effectiveness of screening. Hum Reprod Update. 2010;16(2):189-204. DOI: https://doi.org/10.1093/humupd/dmp035
Lanjouw E, Ossewaarde JM, Stary A et al. 2010 European guideline for the management of Chlamydia trachomatis infections. Int J STD AIDS. 2010;21(11):729-737. DOI: https://doi.org/10.1258/ijsa.2010.010302
Centers for Disease Control and Prevention. Recommendations for the laboratory-based detection of Chlamydia trachomatis and Neisseria gonorrhoeae--2014. MMWR Recomm Rep. 2014;63(RR-02):1-19. [PMCid:PMC4047970]
See H, Lachenaud J, Alberti C et al. Outcome of very preterm infants with Mycoplasma/Ureaplasma airway colonization treated with josamycine. Acta Paediatr. 2010;99(4):625-626. DOI: https://doi.org/10.1111/j.1651-2227.2009.01658.x
Sherrard J, Donders G, White D et al. European (IUSTI/WHO) Guideline on the Management of vaginal Discharge, 2011. Int J STD AIDS. 2011;22(8):421-429. DOI: https://doi.org/10.1258/ijsa.2011.011012
Workowski KA. Sexually Transmitted Infection and HIV: Diagnosis and Treatment. Topics in Antiviral Medicine. 2012;20(1):11-16. [PMid:22538245]
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