Use of Antifungal Creams in the Combined Treatment of Obliterating Diseases of Lower Extremities Arteries
PDF

Keywords

diabetes mellitus
obliterating atherosclerosis of the lower extremities
dermatomycosis
onychomycosis

Abstract

To perform clinical analysis of the effectiveness of the complex treatment of occlusive vascular diseases and fungal lesions of feet with addition of local antifungal medicines. Materials and Methods. The results of examination and treatment of five patients with obliterating diseases of the lower limb vessels and diabetes mellitus with dermatomycosis and onychomycosis of the feet were analyzed. Onychomycosis or mycosis of feet were treated with the help of the combination of the following antifungal creams was used in the treatment: miconazole, clotrimazole, tioconazole in a ratio of 1:1:6.5 contained in the combined preparation cream “XaTonic”. Results and discussion. The use of an antifungal mixture of creams after 7 days has led to the disappearance of the clinical manifestations of dermatomycosis of the feet in three patients, and in two patients with onychomycosis after 14 days there was the reduction of clinical symptoms. Conclusions. The combination of three local antifungal components: miconazole, clotrimazole, thioconazole is effective in treatment of dermatomycosis of the feet. In the treatment of fungal lesions of the feet by dermatologists in patients aged after fifty years, an angiologist/vascular surgeon’s consultation is required.
https://doi.org/10.21802/gmj.2019.1.14
PDF

References

Kryzyna O. Trofichni porushennya m'yakyx tkanyn nyzhnix kincivok pry cukrovomu diabeti druhoho typu (ohlyad). Klinichna endokrynolohiya ta endokrynna xirurhiya. 2018; 1 (61):15-24. http://jcees.endocenter.kiev.ua/article/download/126901/121996

Fukunaga A, Washio K, Ogura K, Taguchi K, Chiyomaru K, Ohno Y, et al. Onychomycosis as a warning sign for peripheral arterial disease. Acta dermato-venereologica. 2013; 93(6): 747-748. DOI: https://doi.org/10.2340/00015555-1576 [PMid:23529206]

Akkus G, Evran M, Gungor D, Karakas M, Sert M, Tetiker T. Tinea pedis and onychomycosis frequency in diabetes mellitus patients and diabetic foot ulcers. A cross sectional–observational study. Pakistan journal of medical sciences. 2016; 32(4): 891. [PMid:27648034 PMCid:PMC5017097]

Mayser P, Freund V, Budihardja D. Toenail onychomycosis in diabetic patients. American journal of clinical dermatology. 2009; 10(4): 211-220. DOI: https://doi.org/10.2165/00128071-200910040-00001 [PMid:19489654]

Matricciani L, Talbot K, Jones S. Safety and efficacy of tinea pedis and onychomycosis treatment in people with diabetes: a systematic review. Journal of foot and ankle research. 2011; 4(1): 26. DOI: https://doi.org/10.1186/1757-1146-4-26 [PMid:22136082 PMCid:PMC3248359]

"Nail Fungus." XaTonic, https://www.xatonic.com/index.php/nail-fungus/

Yaemsiri S, Hou N, Slining M, He K. Growth rate of human fingernails and toenails in healthy American young adults. Journal of the European Academy of Dermatology and Venereology. 2010; 24(4): 420-423. DOI: https://doi.org/10.1111/j.1468-3083.2009.03426.x [PMid:19744178]

Koster MI. Making an epidermis. Annals of the New York Academy of Sciences. 2009; 1170(1): 7-10. DOI: https://doi.org/10.1111/j.1749-6632.2009.04363.x [PMid:19686098 PMCid:PMC2861991]

Piraccini B, Alessandrini A. Onychomycosis: a review. Journal of Fungi. 2015; 1(1): 30-43. DOI: https://doi.org/10.3390/jof1010030 [PMid:29376897 PMCid:PMC5770011]

Toukabri N, Dhieb C, El Euch D, Rouissi M, Mokni M, Sadfi-Zouaoui N. Prevalence, etiology, and risk factors of tinea pedis and tinea unguium in Tunisia. Canadian Journal of Infectious Diseases and Medical Microbiology. 2017; 2017. DOI: https://doi.org/10.1155/2017/6835725

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Downloads

Download data is not yet available.