The Prognostic Value of the Change in the Concentration of C–Reactive Protein in the Oral Liquid of Patients with Acantholytic Pemphigus, in Varying Degrees of the Acantholytic Process Severity on the Mucous Membrane of the Oral Cavity
The interconnection of changes in the concentration of C – reactive protein with the severity degree of the acantholytic process on the mucous membrane of the oral cavity in patients suffering from acantholytic pemphigus is described in the article.
Objective of the study – is to determine the correlation between the concentration of C – reactive protein in the oral liquid of patients with acantholytic pemphigus with the severity degree of the acantholytic process during the period of exacerbation of the disease in order to predict the assessment of general and local therapy, as well as the dynamics of the course of pathological processes on the oral mucous membrane.
Materials and methods. A complex of studies was performed in patients with acantholytic pemphigus, aged from 45 to 63 years, which included oral liquid examination in order to determine the CRP level, and determination of the acantholytic process severity degree on the mucous membrane of the oral cavity (utility model patent №101844).
Results and discussion. There was a clear correlation between the level of CRP concentration in the oral liquid of patients with acantholytic pemphigus with the severity degree of acantholytic process on the mucous membrane of the oral cavity, during different periods of the disease exacerbation. During the first day of exacerbation, the level of CRP was 384 (mg/ml), or higher in 41 individuals, with the third (III) severity degree of the acantholytic process on the mucous membrane of the oral cavity, which was a 73.21% of the total number of examined patients. During the 7th day, the CRP concentration level decreased to values of ≥24 and ≥48 (mg/ml), and during the 14th day – to the values of ≥12 and ≥24 (mg/ml).
Conclusions. The obtained results showed that the change in the concentration of CRP in the oral liquid of patients with acantholytic pemphigus has a reliable prognostic value and is an important characteristic of local and general diagnostic parameters of the disease.
Hasiuk NV, Ivanytsky IYu, Popovych IYu. The prevalence and aspects of diagnosis of acantholytic pemphigus in the practice of a dentist. Actual problems of modern medicine. 2013; 3: 16-18.
Hlukhenky BT, Hrando SA. Immune-dependent dermatoses. Kyiv: Health. 1990; 476.
Goldshtein LM, Tkach VYe. Diagnosis of pemphigus. Methods of examination of patients with skin and venereal diseases. Kyiv: Health. 1987; 164-166.
Kishkun AA. Guidance on laboratory methods of diagnosis. Moscow: 2010; 704.
Amagai M. The molecular logic of pemphigus and impetigo: the desmoglein story. Vet Dermatol. 2009; 20: 308-312. DOI: https://doi.org/10.1111/j.1365-3164.2009.00831.x [PMid:20178466]
Pasceri V, Willerson GT. Direct proinflammatory affect of C-reactive protein on human endothelial cells. Circulation. 2000; 102: 2165-2168. DOI: https://doi.org/10.1161/01.CIR.102.18.2165 [PMid:11056086]
Stanley JR, Amagai M. Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. N Eng J Med. 2006; 355: 1800-1810. DOI: https://doi.org/10.1056/NEJMra061111 [PMid:17065642]
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