Comparative evaluation of the use of a chitosan-based multicomponent remedy in patients with acantholytic lesion of the tissues of the prosthetic bed to provide conditions for the use of removable dentures
AbstractThe article describes the offered by us multicomponent remedy based on chitosan, to provide analgesic and wound-healing effect in patients with acantholytic lesions of the prosthetic bed tissues. Objective of the study. To improve the conditions of removable dentures use for patients with acantholytic pemphigus. Materials and methods. The study involved 56 patients with acantholytic pemphigus, aged from 45 to 63 years old, who were divided into 2 clinical groups. The main group used the proposed remedy; the comparative group received the standard local pemphigus treatment. Methods for determining the area of mucus lesion and the method for determining the intensity of pain syndrome were used to evaluate the final results. Results of the study and their discussion. The average value of visual analogue scale (VAS) was 4.76±0.56 cm in patients of the main group during the first day. During the 7th and 14th day, the value decreased to 2.4±0.28 cm and 1.87±0.12 cm, respectively. In patients of the comparison group, the average value of VAS was 5.07±0.36 cm as for the first day and 4.45±0.45 and 2.36±0.17 cm during the 7th and 14th days, respectively. The ratio of the mean value of the affected area in patients of the main group and the comparison group was 1.04 during the first day, and during the 7th and 14th day the area of injury in patients of the main group was lower 1.29- and 1.84 -fold, respectively. Conclusions The results of the study confirm the necessity of using a multicomponent remedy based on chitosan together with the removable dentures in patients with acantholytic pemphigus, due to its clearly expressed epithelial and analgesic action.
Goldstein LM, Tkach VYe. Diagnosis of pemphigus. Methods of examination of patients with skin and venereal diseases. Zdorovya. 1987; 164-166.
Nikolishyn AK. Diseases of the mucous membrane of the oral cavity. Teaching manual for self-work of students and subordinates. Poltava. 1994; 51.
Nurieva Natalya Sergeevna. Method for determining the area of damage of the oral mucous membrane and the red border of the lips with the help of silicone impression materials. The owners of the patent RU 2404703: Nurieva Natalya Sergeevna (RU), Filimonova Olga Ivanovna (RU), Kozlov Maxim Evgeniyevna (RU), Sobolev Maksim Sergeevich (RU), Nurieva Natalya Sergeevna (RU), Pendzhieva Maryam Muradovna (RU).
Pestov A, Bondar Yu. Dental materials made from chitosan and carboxyethyl chitosan. Modern perspectives in the study of chitin and chitosan: a collection of scientific papers: Proceedings of the VIII International Conference. Moscow. 2006; 2330-2336.
Amagai M. The molecular logic of pemphigus and impetigo: the desmoglein story. Vet Dermatol. 2009; 20: 308-312. DOI: https://doi.org/10.1111/j.1365-3164.2009.00831.x [PMid:20178466]
Calvo P, Ramunen-Lopez C, Vila-Yato JL. Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines. Pharm Res. 1997; 14: 1431-1436. DOI: https://doi.org/10.1023/A:1012128907225 [PMid:9358557]
Sayin B, Somavarapu S. Mono-N-carboxymethyl chitosan (MCC) and N-trimethyl chitosan (TMC) nanoparticles for non-invasive vaccine delivery. Int J Pharm. 2008; 363: 139-148. DOI: https://doi.org/10.1016/j.ijpharm.2008.06.029 [PMid:18662762]
Stanley JR, Amagai M. Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. N Eng J Med. 2006; 355: 1800-1810. DOI: https://doi.org/10.1056/NEJMra061111 [PMid:17065642]
Vila A, Sanchez A. Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice. Eur J Pharm Biopharm. 2004; 57: 123-131. DOI: https://doi.org/10.1016/j.ejpb.2003.09.006 [PMid:14729088]
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