Cover Image

Frequency and Spectrum of Chromosomal Aberrations, Acrocentric Chromosome Associations Among Long Livers with Arterial Hypertension and Osteoarthritis Residing in the Carpathian Region

U P Shalamay

Abstract


To maintain thyroid homeostasis, a key role is played not only by the adequate provision of a body with iodine, but also with other essential micronutrients, iron in particular. Iron is involved in the conversion of the amino acid L-phenylalanine into L-tyrosine, which is the part of active center of thyroid peroxidase which catalyzes the reactions of oxidation and organification of iodine during the biosynthesis of thyroid hormones. At the same time, insufficient secretion of thyroid hormones leads to mucinous edema of the gastric mucosa and closure of its ductless glands and reduction in both gastric juice secretion and iron absorption. 

The objective of the research was to determine the influence of latent iron deficiency onto the thyroid status of schoolchildren. 

Materials and methods. The study involved 68 boys and 65 girls at the age 6-11 years (Group I) and 12-18 years (Group II). To assess iron metabolism, the levels of hemoglobin in capillary blood, serum iron and ferritin, serum iron binding capacity were determined. To clarify the thyroid status in blood serum samples, there were determined the content of free triiodothyronine and thyroxine, thyroid-stimulating hormone of adenohypophysis, urinary iodine concentration; the dimension of the thyroid gland was determined and evaluated considering gender as well as body surface area according to the standards of thyroid volume (97 percentile). 

Results. It was established that latent iron deficiency can cause thyroid homeostasis disorders, as indicated by the growth of TSH in blood serum of girls by 37.5% (p<0.01) as compared to the control data. The probability of the formation of thyroid dysfunction significantly increases in case of combined iodine and iron deficiency. The development of subclinical hypothyroidism was established in 90.0% of boys and 89.0% of girls at the age of 6-11 years and 100.0% of boys and 75.0% of girls at the age of 12-18 years with mild iodine deficiency and latent iron deficiency. In schoolchildren with microelementosis, an increase in the thyroid gland was revealed in 66.6% of boys and 75.0% of girls of Group I and in half of boys and girls of Group II.

Conclusions. Iron deficiency can cause changes in thyroid homeostasis even at the stage of preclinical disorders. Latent iron deficiency potentiates the development of subclinical hypothyroidism in case of mild iodine deficiency.


Keywords


children; thyroid status; latent iron deficiency; mild iodine deficiency

Full Text:

HTML PDF

References


Belykh NA. Micronutrient deficiency (iodine and iron) in infants. Sovremennaya pediatriya. 2013;1(49):163–167

Voronych-Semchenko NM, et al. Vplyv mikroelementnoho dysbalansu Prykarpattia na porushennia tyreoiidnoho homeostazu. Naukovo-praktychna konferentsiia, “Vplyv dovkillia Prykarpattia na perebih fiziolohichnykh protsesiv” Ivano-Frankivsk: IFNMU; 2017. p. 29–31

Mamenko MYe. Interaction between iodine and iron deficiency in junior school-age children. Perynatolohiia i pediatriia. 2009;4:80–

Marushko YV, Lisochenko OO. Zalizodefitsytni stany u ditei na suchasnomu etapi. Sovremennaya pediatriya. 2011;1:84–88

Smiyan OI, Vasylyshyn KhI, Klymovets M. Diagnosis of iron deficiency in children: the modern view on the problem. Visnyk SumDU. 2012;1:105–110

Pavlykivska BM. Features of heart rate variability in children with acute diseases of lower respiratory ways against the background of subclinical hypothyroidism. Bukovynskyi medychnyi visnyk. 2016;3(79):139–142

Zimmermann MB. Iodine difeciency. Endocr Rev. 2009;30(4):376–408. DOI: http://doi.org/10.1210/er.2009-0011




DOI: http://dx.doi.org/10.21802/acm.2017.1.9

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 U P Shalamay

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.


IFNMU Logo

Free counters!