Plasma Level of High-Sensitive C-Reactive Protein in Patients with Acute Myocardial Infarction and Arterial Hypertension

Wael Rumaneh

Abstract


Arterial hypertension is an independent predictor of acute myocardial infarction. Nowadays, plasma level of high-sensitive C-reactive protein is a marker of cardiovascular risk. 

The objective of the research was to evaluate plasma level of high-sensitive C-reactive protein in patients with acute myocardial infarction and arterial hypertension depending on myocardial remodeling type. 

Materials and methods. 130 patients with myocardial infarction (63 individuals with concomitant arterial hypertension and 67 individuals without it) were observed. Transthoracic echocardiogram was used. To evaluate plasma level of high-sensitive C-reactive protein the ELISA method was applied. 

Results. Plasma level of high-sensitive C-reactive protein in patients with acute myocardial infarction increased by 5.11 times compared to the control group: (10.67 [5.43; 12.89]) mg/l and (2.09 [1.40; 4.60]) mg/l, respectively (p<0.001). In myocardial infarction and arterial hypertension, this parameter increased by 6.57 times (to (13.73 [7.05; 15.17]) mg/l) (p<0.001), and by 1.27 times (p<0.05) as compared to patients without arterial hypertension. No differences in plasma level of high-sensitive C-reactive protein were detected in patients with different types of left ventricular remodeling.

Conclusions. Acute myocardial infarction caused by high plasma level of high-sensitive C-reactive protein is severer in co-existent arterial hypertension. There are no differences in blood levels of high-sensitive C-reactive protein depending on the type of left ventricular remodeling.


Keywords


myocardial infarction; arterial hypertension; high-sensitive C-reactive protein; left ventricular remodeling

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References


Roger VL. Epidemiology of myocardial infarction. Med Clin North Am. 2007;91:537–552. DOI: http://doi.org/10.1016/j.mcna.2007.03.007

Nichols M, Townsend N, Scarborough P, et al. Cardiovascular disease in Europe 2014: epidemiological update. Eur Heart J. 2014;35:2950–2959. DOI: http://doi.org/10.1093/eurheartj/ehu299

Mozaffarian D, Benjamin EJ, et al. Executive Summary: Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation. 2016;133:447–454. DOI: http://doi.org/10.1161/CIR.0000000000000366 [PMid: 26811276]

Sanchis-Gomar F, Perez-Quilis C, Leischik R, Lucia A. Epidemiology of coronary heart disease and acute coronary syndrome. Annals of Translational Medicine. 2016;4(13):256 DOI: http://doi.org/10.21037/atm.2016.06.33

Kintcher U. The burden of hypertension. EuroIntervantion. 2013;9:9–15. DOI: http://doi.org/10.4244/EIJV9SRA3

Lewington S, Clarke R, Qizilbash N, et al. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903–1913. DOI: http://doi.org/10.1016/S0140-6736(02)11911-8

Pfutzner A, Forst T. High-sensitive C-reactive protein as cardiovascular risk marker in patients with diabetes mellitus. Diabetes Technol. Ther. 2006;8:28–36. DOI: http://doi.org/10.1089/dia.2006.8.28

Lang RM, Bierig M, Devereux RB, Flachskampf FA, et al. American Society of Echocardiography's Guidelines and Standards Committee; European Association of Echocardiography. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440–1463. DOI: http://doi.org/10.1016/j.echo.2005.10.005

Ghali JK, Liao J, Cooper RS. Influence of left ventricle geometric patterns on prognosis in patients with or without of coronary artery disease. JACC. 1998;31:1635–1640. DOI: http://doi.org/10.1016/S0735-1097(98)00131-4

Rashidnijad D, Hosseine SM, Moazenzadeh M, et al. Relationship between serum level of high-sensitive C-reactive protein and extension of myocardial involvement in patients with acute myocardial infarction. Rom. J. Intern. Med. 2012;50:211–215

Badiger Raju H, Dinesha V, Hosalli Arjun, Ashwin SP. Hs-C-reactive protein as an indicator for prognosis in acute myocardial infarction. J. Scie. Soc. 2014;41:118–121. DOI: http://doi.org/10.4103/0974-5009.132859




DOI: http://dx.doi.org/10.21802/acm.2017.1.7

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