Substantiation of Initial-I Stage of Generalized Periodontitis Complex Treatment Choice Among Medical University Students According to Indicators’ Dynamics Changes of Oral Cavity Prooxidant-antioxidant System
AbstractAccording to the results of epidemiological studies, the spread of periodontal tissue diseases has tendency to increase, despite recent decades’ significant achievements in dentistry. Studies of periodontal tissue diseases pathogenesis have found that oxygen-dependent production of reactive oxygen species (ROS) and antioxidant activity are involved in the pathogenic mechanism of the disease. ROS are highly toxic and can induce lipid peroxidation (LPO). Researchers have shown increased levels of LPO with generalized periodontitis (GP). "Noofen" is one of the drugs that normalizes the processes of LPO and shows positive effect in GP treatment. That is why in advanced complex treatment of generalized periodontitis of initial-I stage, we’ve used this pill. The objective of the study was to analyze the efficiency of nootropic medicine "Noofen" usage in suggested initial-I stage of generalized periodontitis treatment, taking into account the dynamics of oral fluid prooxidant and antioxidant indicators among students with high level of emotional sensitivity. Materials and methods. A study of 2nd year students (174) of Ivano-Frankivsk National Medical University were questioned in order to determine the level of individual emotional states (anxiety, frustration, aggression and rigidity) according to the method of H. Eysenck. Of those who have experienced increased and high level of emotional sensitivity to various stressors and situations, we have selected 50 students with initial-I stage of generalized periodontitis. To determine the efficiency of treatment, two groups were formed: observation (group I) and comparison (group II). Each group consisted of 25 individuals who were treated and monitored dynamically during the year. The condition of oral cavity prooxidant system was determined by the level of malondialdehyde (MDA) and diene conjugates (DC). To study the state of the antioxidant protection system, the activity of superoxide dismutase (SOD), glutathione-S-transferase (G-ST) and glutathione peroxidase (GPO) were determined. The advanced treatment, which included oral rinsing with "Octenisept" solution, dissolving of tablets "Lizak", intake of medicine "Noofen" and vitamin-microelement complex "Vita-Supradin Active". Conclusions. The results of the performed treatment indicate that the use of advanced therapy of GP is significantly more effective, confirmed by prooxidant-antioxidant system parameters of oral fluid in the long term, compared with traditional treatment.
Kholodnyak OV, Dobrovolskaya MK. The effectiveness of treatment of localized periodontal tissue diseases in young people according to the study of the rate of salivation and acid-base balance in the oral cavity. Clinical dentistry. 2015; 3-4: 46-52. [published in Ukrainian]
Slootweg PJ. Dental pathology. Springer; 2007. 83 р. DOI: https://doi.org/10.1007/978-3-540-71691-4 [PMCid:PMC2807505]
Wei D, Zhang X‐L, Wang Y‐Z, Yang C‐X, G Chen. Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy. Australian Dental Journal. [Internet]. 2010 March. DOI: https://doi.org/10.1111/j.1834-7819.2009.01123.x [PMid:20415915]
Canakci CF, Cicek Y, Canakci V. Reactive oxygen species and human inflammatory periodontal diseases. Biochemistry (Mosc). [Internet]. 2005 Jun;70:619-628. DOI: https://doi.org/10.1007/s10541-005-0161-9 [PMid:16038603]
Waddington RJ, Moseley R, Embery G. Reactive oxygen species: a potential role in the pathogenesis of periodontal diseases. Oral Dis. [Internet]. 2000 May;6(3):138-151. DOI: https://doi.org/10.1111/j.1601-0825.2000.tb00325.x [PMid:10822357]
Ornoy A. Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy. Reprod Toxicol. [Internet]. 2007 Jul;24(1):31-41. DOI: https://doi.org/10.1016/j.reprotox.2007.04.004 [PMid:17548185]
Del Rio D, Serafini M, Pellegrini N. Selected methodologies to assess oxidative/antioxidant status in vivo: a critical review. Nutr Metab Cardiovasc Dis. [Internet]. 2002 Dec;12(6):343-351.
Del Rio D, Stewart AJ, Pellegrini N. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis. [Internet]. 2005 Aug;15(4):316-328. DOI: https://doi.org/10.1016/j.numecd.2005.05.003 [PMid:16054557]
Manasa Ambati, Koduganti Rekha Rani, Panthula Veerendranath Reddy, Jammula Suryaprasanna,Rajashree Dasari, Himabindu Gireddy. Evaluation of oxidative stress in chronic periodontitis patients following systemic antioxidant supplementation: A clinical and biochemical study. J Nat Sci Biol Med. [Internet]. 2017;8(1):99-103. DOI: https://doi.org/10.4103/0976-9668.198366 [PMid:28250683 PMCid:PMC5320832]
Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. [Internet]. 2007;39(1):44-84. DOI: https://doi.org/10.1016/j.biocel.2006.07.001 [PMid:16978905]
Canakci V, Yildirim A, Canakci CF, Eltas A, Cicek Y, Canakci H. Total antioxidant capacity and antioxidant enzymes in serum, saliva, and gingival crevicular fluid of preeclamptic women with and without periodontal disease. J Periodontol. [Internet]. 2007;78(8):1602-1611. DOI: https://doi.org/10.1902/jop.2007.060469 [PMid:17668980]
Chapple IL, Brock GR, Milward MR, Ling N, Matthews JB. Compromised GCF total antioxidant capacity in periodontitis: cause or effect? J Clin Periodontol. [Internet]. 2007;34(2):103-110. DOI: https://doi.org/10.1111/j.1600-051X.2006.01029.x [PMid:17214737]
Tsai CC, Chen HS, Chen SL, Ho YP, Ho KY, Wu YM et al. Lipid peroxidation: a possible role in the induction and progression of chronic periodontitis. J Periodontal Res. [Internet]. 2005;40(5):378-384. DOI: https://doi.org/10.1111/j.1600-0765.2005.00818.x [PMid:16105090]
Danilevsky MF, Borisenko AB, Politun AM, Antonenko MJ, Siedelnikova LF, Nesin OF. Therapeutic dentistry. Book 3, Periodontal Disease. Kyiv: Medicine; 2008. 614s. [published in Ukrainian]
Magalyas VM, Mikheyev AO, Horny SE. Modern Methods of Experimental and Clinical Research at the BSMA Central Research Laboratory. Chernivtsi: BDMA 2001. 42s. [published in Ukrainian]
Gerush IV, Meshchishen IF. The state of the glutathione blood system under experimental ulcerative lesions of the gastroduodenal zone and the action of tincture of purple echinacea. Bulletin of problems of biology and medicine. 1998; 7: 10-15. [published in Ukrainian]
Godovanets OI. Long-term results of the use of antioxidant drugs in the treatment of chronic catarrhal gingivitis in children. The world of medicine and biology. 2012; 3: 80-83. [published in Ukrainian]
Copyright (c) 2019 Tetiana Pavliuk, Mykola Rozhko, Oksana Panchak
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).