Optimization of the Prediction of Arterial Hypertension Development in the Patients with Type 2 Diabetes Mellitus on the Background of Undifferentiated Connective Tissue Dysplasia

  • Liudmyla Sherstiuk V. N. Karazin Kharkiv National University, Kharkiv, Ukraine
Keywords: diabetes mellitus, undifferentiated connective tissue dysplasia, arterial hypertension, prognostication


In recent years, disorders of connective tissue metabolism that are involved in the pathogenesis of many diseases have attracted increasing attention. They are of particular importance in the presence of connective tissue dysplasia. Undifferentiated forms, being a frequent component of comorbid pathology, are quite widespread among the general population. Among comorbidities, arterial hypertension, diabetes mellitus and undifferentiated connective tissue dysplasia in various combinations are more often observed.   The objective of the research was to determine the prognostic significance of undifferentiated connective tissue dysplasia in the development of arterial hypertension in the patients with type 2 diabetes mellitus. Materials and methods. To determine the prognostic significance of undifferentiated connective tissue dysplasia in the development of arterial hypertension, there was conducted an analysis of hospital discharge reports received by the patients with type 2 diabetes mellitus duration of at least 2 years who were treated two to five years ago. The predictive significance of the factors selected for the analysis was determined through applying the regression analysis using a logistic regression model, the Wald test. Results. The test for coincidence of the predicted and observed values revealed that the specificity of the regression model was 87.2%, while its sensitivity was 89.7%. The overall predictability was 88.5%. Conclusions. These are quite high indicators that allow us to apply the proposed model to detect the patients with type 2 diabetes mellitus being at high risk of arterial hypertension.


Belovol AN, Shkolnik VV, Fadeyenko HD, Tveretinov AB. Gipertonicheskaya bolezn i ozhireniye. Ternopol: THMU; c2013. 344p.

Kadurina TI, Gorbunova VN. Displaziya soyedinitelnoy tkani. Rukovodstvo dlya vrachey. Saint Petersburg: Elbi-SPb; c2009. 704p.

Kovalenko VM, Kornatskyi VM. Problemy zdorovia i tryvalosti zhyttia v suchasnykh umovakh. Kovalenko VM, Kornatskyi VM, editors. Kyiv. c2017. 300p.

Martynova AI, Nechayeva GI. Natsionalnyye rekomendatsiyi rossiyskogo nauchnogo meditsinskogo obshchestva terapevtov po diagnostike, lecheniyu i reabilitatsiyi patsiyentov s displaziyami soyedinitelnoy tkani. Moscow: OOO "Bionika-Media": c2016. 80p.

Maslova IS, Kurnikova IA. Osobennosti techeniya sakharnogo diabeta tipa 2 v sochetaniyi s patologiyey soyedinitelnoy tkani. Fundamentalnyye issledovaniya. 2010;8:41-45.

Sirenko YuN, Radchenko AD, Slashcheva TH. Risk stratification of patients with hypertension and type 2 diabetes mellitus: results of Ukrainian multicenter observational study Status. Arterial Hypertension. 2014;2:9-19 [published in Russian]

Baron-Franco B, McLean G, Mair FS et al. Comorbidity and polypharmacy in chronic heart failure: a large cross-sectional study in primary care. Br J Gen Pract. 2017;67(658):e314-e320. DOI: https://doi.org/10.3399/bjgp17X690533 [PMid:28396366 PMCid:PMC5409437]

Charvát J. What is the significance of the phenomenon of hypertension in disguise in patients with type 2 diabetes mellitus treated for long-lasting hypertension? Vnitr Lek. 2016;62(3):215-217. [published in Czech]

Cifkova R. Epidemiology of hypertension. Manual of hypertension of the European Society of Hypertension. Mancia G, Grassi G, Redon J, editors. 2014;1-13 DOI: https://doi.org/10.1201/b17072-2

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